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LPCAT2

GENERAL INFORMATION

Gene name

 LPCAT2

Gene description

 Lysophosphatidylcholine acyltransferase 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, HMC-1, WM-115)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues, highest in thyroid gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA007891
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and colorectal cancer (favourable).
Endometrial cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA007891

GENE INFORMATION

Gene name

 LPCAT2 (HGNC Symbol)

Synonyms

 AGPAT11, AYTL1, FLJ20481, LysoPAFAT

Description

 Lysophosphatidylcholine acyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

Chromosome

 16

Cytoband

 q12.2

Chromosome location (bp)

 55508998 - 55586670

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087253 (version 83.38)

Entrez gene

 54947

UniProt

 Q7L5N7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L5N7

Antibodypedia

 LPCAT2 antibodies

PROTEIN BROWSER
LPCAT2-001
LPCAT2-004
LPCAT2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPCAT2-001
ENSP00000262134
ENST00000262134
Q7L5N7 [Direct mapping]
Lysophosphatidylcholine acyltransferase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity]
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005795 [Golgi stack]
GO:0005811 [lipid particle]
GO:0006644 [phospholipid metabolic process]
GO:0006663 [platelet activating factor biosynthetic process]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity]
GO:0047192 [1-alkylglycerophosphocholine O-acetyltransferase activity]
GO:0061024 [membrane organization]
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 544 aa
60.2 kDa 		No 2
LPCAT2-004
ENSP00000457496
ENST00000564084
H3BU68 [Direct mapping]
Lysophosphatidylcholine acyltransferase 2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
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 188 aa
21.4 kDa 		No 0
LPCAT2-201
ENSP00000483225
ENST00000615823
A0A087X0A3 [Direct mapping]
Lysophosphatidylcholine acyltransferase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 252 aa
28.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.