Cell atlas - NOP14 - The Human Protein Atlas

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NOP14

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NOP14
Gene description	NOP14 nucleolar protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated), Nucleoli (validated)
Mouse	Localized to the Nucleoli in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA039596 , HPA055652
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (validated), Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039596	A-431	Nucleus
	HPA039596	A-431	Nucleoli
	HPA039596	U-2 OS	Nucleus
	HPA039596	U-2 OS	Nucleoli
	HPA039596	U-251 MG	Nucleus
	HPA039596	U-251 MG	Nucleoli
	HPA055652	PC-3	Nucleus
	HPA055652	PC-3	Nucleoli
	HPA055652	U-251 MG	Nucleus
	HPA055652	U-251 MG	Nucleoli

MOUSE CELLS

Main location

Nucleoli

Additional location

Nucleus

Mouse gene

ENSMUSG00000036693 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055652	NIH 3T3	Nucleus
	HPA055652	NIH 3T3	Nucleoli

GENE INFORMATION
Gene name	NOP14 (HGNC Symbol)
Synonyms	C4orf9, NOL14, RES4-25, UTP2
Description	NOP14 nucleolar protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	2937933 - 2963385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087269 (version 83.38)
Entrez gene	8602
UniProt	P78316 (UniProt - Evidence at protein level)
neXtProt	NX_P78316
Antibodypedia	NOP14 antibodies

PROTEIN BROWSER

NOP14-002	NOP14-003	NOP14-004	NOP14-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOP14-002 ENSP00000315674 ENST00000314262	P78316 [Direct mapping] Nucleolar protein 14 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000472 [endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000480 [endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006364 [rRNA processing] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0030490 [maturation of SSU-rRNA] GO:0030515 [snoRNA binding] GO:0030686 [90S preribosome] GO:0030692 [Noc4p-Nop14p complex] GO:0032040 [small-subunit processome] GO:0042274 [ribosomal small subunit biogenesis] GO:0044822 [poly(A) RNA binding] Show all	857 aa 97.7 kDa	No	0
NOP14-003 ENSP00000381146 ENST00000398071	P78316 [Direct mapping] Nucleolar protein 14 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000472 [endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000480 [endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006364 [rRNA processing] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0030490 [maturation of SSU-rRNA] GO:0030515 [snoRNA binding] GO:0030686 [90S preribosome] GO:0030692 [Noc4p-Nop14p complex] GO:0032040 [small-subunit processome] GO:0042274 [ribosomal small subunit biogenesis] GO:0044822 [poly(A) RNA binding] Show all	806 aa 91.4 kDa	No	0
NOP14-004 ENSP00000405068 ENST00000416614	P78316 [Direct mapping] Nucleolar protein 14 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000472 [endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000480 [endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006364 [rRNA processing] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0030490 [maturation of SSU-rRNA] GO:0030515 [snoRNA binding] GO:0030686 [90S preribosome] GO:0030692 [Noc4p-Nop14p complex] GO:0032040 [small-subunit processome] GO:0042274 [ribosomal small subunit biogenesis] GO:0044822 [poly(A) RNA binding] Show all	857 aa 97.7 kDa	No	0
NOP14-005 ENSP00000427415 ENST00000502735	E9PFK5 [Direct mapping] Nucleolar protein 14 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0030490 [maturation of SSU-rRNA] GO:0030692 [Noc4p-Nop14p complex] GO:0032040 [small-subunit processome] Show all	788 aa 88.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.