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ADD1

GENERAL INFORMATION

Gene name

 ADD1

Gene description

 Adducin 1 (alpha)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA035873 , HPA035874 , CAB009794
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035873
HPA035874
CAB009794

GENE INFORMATION

Gene name

 ADD1

Synonyms

Description

 Adducin 1 (alpha) (HGNC Symbol)

Entrez gene summary

 Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 2843857 - 2930076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087274 (version 83.38)

Entrez gene

 118

UniProt

 P35611 (UniProt - Evidence at protein level)

neXtProt

 NX_P35611

Antibodypedia

 ADD1 antibodies

PROTEIN BROWSER
«
ADD1-001
ADD1-002
ADD1-003
ADD1-009
ADD1-011
ADD1-013
ADD1-014
ADD1-015
ADD1-022
ADD1-023
ADD1-201
ADD1-202
ADD1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADD1-001
ENSP00000381197
ENST00000398129
P35611 [Direct mapping]
Alpha-adducin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008134 [transcription factor binding]
GO:0008290 [F-actin capping protein complex]
GO:0012501 [programmed cell death]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032092 [positive regulation of protein binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
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 737 aa
81 kDa 		No 0
ADD1-002
ENSP00000348100
ENST00000355842
P35611 [Direct mapping]
Alpha-adducin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008134 [transcription factor binding]
GO:0008290 [F-actin capping protein complex]
GO:0012501 [programmed cell death]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032092 [positive regulation of protein binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
Show all
 662 aa
73.4 kDa 		No 0
ADD1-003
ENSP00000381191
ENST00000398123
P35611 [Direct mapping]
Alpha-adducin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008134 [transcription factor binding]
GO:0008290 [F-actin capping protein complex]
GO:0012501 [programmed cell death]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032092 [positive regulation of protein binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
Show all
 662 aa
73.3 kDa 		No 0
ADD1-009
ENSP00000426700
ENST00000508277
D6RF25 [Direct mapping]
Alpha-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 143 aa
15.9 kDa 		No 0
ADD1-011
ENSP00000421918
ENST00000511797
D6RAH3 [Direct mapping]
Alpha-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 137 aa
15.3 kDa 		No 0
ADD1-013
ENSP00000423024
ENST00000503455
E7ENY0 [Direct mapping]
Alpha-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0045111 [intermediate filament cytoskeleton]
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 663 aa
73.4 kDa 		No 0
ADD1-014
ENSP00000421907
ENST00000513328
E7EV99 [Direct mapping]
Alpha-adducin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0045111 [intermediate filament cytoskeleton]
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 632 aa
70.1 kDa 		No 0
ADD1-015
ENSP00000424143
ENST00000514940
H0Y9H2 [Direct mapping]
Alpha-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 444 aa
48.4 kDa 		No 0
ADD1-022
ENSP00000438069
ENST00000536424
H0YFD8 [Direct mapping]
Alpha-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 105 aa
12.1 kDa 		No 0
ADD1-023
ENSP00000441388
ENST00000541843
H0YG19 [Direct mapping]
Alpha-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 114 aa
12.8 kDa 		No 0
ADD1-201
ENSP00000264758
ENST00000264758
P35611 [Direct mapping]
Alpha-adducin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001701 [in utero embryonic development]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006884 [cell volume homeostasis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008134 [transcription factor binding]
GO:0008290 [F-actin capping protein complex]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0020027 [hemoglobin metabolic process]
GO:0030036 [actin cytoskeleton organization]
GO:0030218 [erythrocyte differentiation]
GO:0030507 [spectrin binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032092 [positive regulation of protein binding]
GO:0035264 [multicellular organism growth]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046982 [protein heterodimerization activity]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
Show all
 768 aa
84.3 kDa 		No 0
ADD1-202
ENSP00000381193
ENST00000398125
P35611 [Direct mapping]
Alpha-adducin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008134 [transcription factor binding]
GO:0008290 [F-actin capping protein complex]
GO:0012501 [programmed cell death]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032092 [positive regulation of protein binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
Show all
 662 aa
73.3 kDa 		No 0
ADD1-203
ENSP00000399828
ENST00000446856
A0A0A0MSR2 [Direct mapping]
Alpha-adducin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 400 aa
44 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.