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DNM1L

GENERAL INFORMATION

Gene name

 DNM1L

Gene description

 Dynamin 1-like

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic and membrane expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039324 , CAB009952
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039324
CAB009952

GENE INFORMATION

Gene name

 DNM1L (HGNC Symbol)

Synonyms

 DRP1, DVLP, DYMPLE, HDYNIV, VPS1

Description

 Dynamin 1-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Chromosome

 12

Cytoband

 p11.21

Chromosome location (bp)

 32679200 - 32745650

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087470 (version 83.38)

Entrez gene

 10059

UniProt

 O00429 (UniProt - Evidence at protein level)

neXtProt

 NX_O00429

Antibodypedia

 DNM1L antibodies

PROTEIN BROWSER
«
DNM1L-001
DNM1L-002
DNM1L-003
DNM1L-004
DNM1L-005
DNM1L-008
DNM1L-010
DNM1L-015
DNM1L-016
DNM1L-018
DNM1L-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNM1L-001
ENSP00000415131
ENST00000452533
O00429 [Direct mapping]
Dynamin-1-like protein
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0003374 [dynamin polymerization involved in mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008152 [metabolic process]
GO:0008289 [lipid binding]
GO:0010821 [regulation of mitochondrion organization]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016559 [peroxisome fission]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032459 [regulation of protein oligomerization]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051289 [protein homotetramerization]
GO:0061025 [membrane fusion]
GO:0070266 [necroptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090149 [mitochondrial membrane fission]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1900063 [regulation of peroxisome organization]
GO:1903146 [regulation of mitophagy]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 710 aa
79.4 kDa 		No 0
DNM1L-002
ENSP00000449089
ENST00000553257
O00429 [Direct mapping]
Dynamin-1-like protein
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0003374 [dynamin polymerization involved in mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005903 [brush border]
GO:0005905 [coated pit]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008152 [metabolic process]
GO:0008289 [lipid binding]
GO:0010821 [regulation of mitochondrion organization]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016559 [peroxisome fission]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032459 [regulation of protein oligomerization]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051289 [protein homotetramerization]
GO:0060047 [heart contraction]
GO:0061025 [membrane fusion]
GO:0070266 [necroptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0070585 [protein localization to mitochondrion]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090149 [mitochondrial membrane fission]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1900063 [regulation of peroxisome organization]
GO:1903146 [regulation of mitophagy]
GO:1903578 [regulation of ATP metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 749 aa
83.4 kDa 		No 0
DNM1L-003
ENSP00000450399
ENST00000549701
O00429 [Direct mapping]
Dynamin-1-like protein
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0003374 [dynamin polymerization involved in mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008152 [metabolic process]
GO:0008289 [lipid binding]
GO:0010821 [regulation of mitochondrion organization]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016559 [peroxisome fission]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032459 [regulation of protein oligomerization]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051289 [protein homotetramerization]
GO:0061025 [membrane fusion]
GO:0070266 [necroptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090149 [mitochondrial membrane fission]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1900063 [regulation of peroxisome organization]
GO:1903146 [regulation of mitophagy]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 736 aa
81.9 kDa 		No 0
DNM1L-004
ENSP00000350948
ENST00000358214
G8JLD5 [Direct mapping]
Dynamin-1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016559 [peroxisome fission]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 712 aa
79.6 kDa 		No 0
DNM1L-005
ENSP00000266481
ENST00000266481
O00429 [Direct mapping]
Dynamin-1-like protein
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0003374 [dynamin polymerization involved in mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008152 [metabolic process]
GO:0008289 [lipid binding]
GO:0010821 [regulation of mitochondrion organization]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016559 [peroxisome fission]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032459 [regulation of protein oligomerization]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051289 [protein homotetramerization]
GO:0061025 [membrane fusion]
GO:0070266 [necroptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090149 [mitochondrial membrane fission]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1900063 [regulation of peroxisome organization]
GO:1903146 [regulation of mitophagy]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 699 aa
78.1 kDa 		No 0
DNM1L-008
ENSP00000448610
ENST00000547312
O00429 [Direct mapping]
Dynamin-1-like protein
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0003374 [dynamin polymerization involved in mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008152 [metabolic process]
GO:0008289 [lipid binding]
GO:0010821 [regulation of mitochondrion organization]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016559 [peroxisome fission]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032459 [regulation of protein oligomerization]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051289 [protein homotetramerization]
GO:0061025 [membrane fusion]
GO:0070266 [necroptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090149 [mitochondrial membrane fission]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1900063 [regulation of peroxisome organization]
GO:1903146 [regulation of mitophagy]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 725 aa
80.5 kDa 		No 0
DNM1L-010
ENSP00000370388
ENST00000381000
O00429 [Direct mapping]
Dynamin-1-like protein
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0003374 [dynamin polymerization involved in mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008152 [metabolic process]
GO:0008289 [lipid binding]
GO:0010821 [regulation of mitochondrion organization]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016559 [peroxisome fission]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032459 [regulation of protein oligomerization]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051289 [protein homotetramerization]
GO:0061025 [membrane fusion]
GO:0070266 [necroptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090149 [mitochondrial membrane fission]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1900063 [regulation of peroxisome organization]
GO:1903146 [regulation of mitophagy]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 738 aa
82.1 kDa 		No 0
DNM1L-015
ENSP00000447845
ENST00000551476
F8VUJ9 [Direct mapping]
Dynamin-1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
GO:0016559 [peroxisome fission]
Show all
 172 aa
19.1 kDa 		No 0
DNM1L-016
ENSP00000447013
ENST00000550154
F8W1W3 [Direct mapping]
Dynamin-1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
GO:0016559 [peroxisome fission]
Show all
 169 aa
18.4 kDa 		No 0
DNM1L-018
ENSP00000447788
ENST00000548750
F8VZ52 [Direct mapping]
Dynamin-1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
GO:0016559 [peroxisome fission]
Show all
 261 aa
29 kDa 		No 0
DNM1L-201
ENSP00000404160
ENST00000414834
O00429 [Direct mapping]
Dynamin-1-like protein
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000266 [mitochondrial fission]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0003374 [dynamin polymerization involved in mitochondrial fission]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005905 [coated pit]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008152 [metabolic process]
GO:0008289 [lipid binding]
GO:0010821 [regulation of mitochondrion organization]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016559 [peroxisome fission]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032459 [regulation of protein oligomerization]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051289 [protein homotetramerization]
GO:0061025 [membrane fusion]
GO:0070266 [necroptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090149 [mitochondrial membrane fission]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1900063 [regulation of peroxisome organization]
GO:1903146 [regulation of mitophagy]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 533 aa
60 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.