Expression of ERGIC2 in cancer - Summary - The Human Protein Atlas

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ERGIC2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ERGIC2
Gene description	ERGIC and golgi 2
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049695
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), liver cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049695

GENE INFORMATION
Gene name	ERGIC2 (HGNC Symbol)
Synonyms	Erv41, PTX1
Description	ERGIC and golgi 2 (HGNC Symbol)
Entrez gene summary	ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]
Chromosome	12
Cytoband	p11.22
Chromosome location (bp)	29337352 - 29381189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087502 (version 83.38)
Entrez gene	51290
UniProt	Q96RQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RQ1
Antibodypedia	ERGIC2 antibodies

PROTEIN BROWSER

ERGIC2-001	ERGIC2-002	ERGIC2-003	ERGIC2-004	ERGIC2-005	ERGIC2-007	ERGIC2-009	ERGIC2-011	ERGIC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERGIC2-001 ENSP00000353270 ENST00000360150	Q96RQ1 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 A0A024RB08 [Target identity:100%; Query identity:100%] ERGIC and golgi 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	377 aa 42.5 kDa	No	2
ERGIC2-002 ENSP00000450042 ENST00000546839	F8VPA6 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0043231 [intracellular membrane-bounded organelle] Show all	220 aa 24.9 kDa	No	1
ERGIC2-003 ENSP00000448426 ENST00000552132	F8VR88 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0043231 [intracellular membrane-bounded organelle] Show all	175 aa 19.9 kDa	No	1
ERGIC2-004 ENSP00000449691 ENST00000552155	F8VUZ2 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		203 aa 22.9 kDa	No	1
ERGIC2-005 ENSP00000448535 ENST00000551467	H0YI50 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		209 aa 23.2 kDa	No	1
ERGIC2-007 ENSP00000448482 ENST00000548441	F8VRW9 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		71 aa 8.2 kDa	No	1
ERGIC2-009 ENSP00000448585 ENST00000548909	H0YI58 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.3 kDa	No	0
ERGIC2-011 ENSP00000447165 ENST00000550353	F8W0R1 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0043231 [intracellular membrane-bounded organelle] Show all	172 aa 19.5 kDa	No	0
ERGIC2-201 ENSP00000478266 ENST00000611644	A0A087WU02 [Direct mapping] Endoplasmic reticulum-Golgi intermediate compartment protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		386 aa 43.4 kDa	No	2

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The Human Protein Atlas

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