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AURKA

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GENERAL INFORMATION

Gene name

 AURKA

Gene description

 Aurora kinase A

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus, cytosol & centrosome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Centrosome (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA002636
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus, cytosol & centrosome.

Main location

 Nucleus (approved), Centrosome (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA002636 A-431 Nucleus
Centrosome
Cytosol
HPA002636 U-251 MG Nucleus
Centrosome
Cytosol

GENE INFORMATION

Gene name

 AURKA (HGNC Symbol)

Synonyms

 AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7

Description

 Aurora kinase A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.2

Chromosome location (bp)

 56369389 - 56392337

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087586 (version 83.38)

Entrez gene

 6790

UniProt

 O14965 (UniProt - Evidence at protein level)

neXtProt

 NX_O14965

Antibodypedia

 AURKA antibodies

PROTEIN BROWSER
«
AURKA-001
AURKA-002
AURKA-003
AURKA-004
AURKA-005
AURKA-006
AURKA-007
AURKA-008
AURKA-009
AURKA-010
AURKA-011
AURKA-012
AURKA-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AURKA-001
ENSP00000216911
ENST00000347343
O14965 [Direct mapping]
Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007057 [spindle assembly involved in female meiosis I]
GO:0007067 [mitotic nuclear division]
GO:0007100 [mitotic centrosome separation]
GO:0007126 [meiotic nuclear division]
GO:0009948 [anterior/posterior axis specification]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031616 [spindle pole centrosome]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032355 [response to estradiol]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0042585 [germinal vesicle]
GO:0043066 [negative regulation of apoptotic process]
GO:0043146 [spindle stabilization]
GO:0043203 [axon hillock]
GO:0045120 [pronucleus]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051297 [centrosome organization]
GO:0051301 [cell division]
GO:0051642 [centrosome localization]
GO:0071539 [protein localization to centrosome]
GO:0072686 [mitotic spindle]
GO:0072687 [meiotic spindle]
GO:1900195 [positive regulation of oocyte maturation]
GO:1990138 [neuron projection extension]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-002
ENSP00000393452
ENST00000441357
Q5QPD4 [Direct mapping]
Aurora kinase A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000212 [meiotic spindle organization]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007100 [mitotic centrosome separation]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0051233 [spindle midzone]
Show all
 271 aa
30.7 kDa 		No 0
AURKA-003
ENSP00000379251
ENST00000395915
O14965 [Direct mapping]
Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043146 [spindle stabilization]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-004
ENSP00000321591
ENST00000312783
O14965 [Direct mapping]
Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043146 [spindle stabilization]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-005
ENSP00000360407
ENST00000371356
O14965 [Direct mapping]
Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043146 [spindle stabilization]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-006
ENSP00000379249
ENST00000395913
O14965 [Direct mapping]
Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043146 [spindle stabilization]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-007
ENSP00000405170
ENST00000456249
Q5QPD1 [Direct mapping]
Aurora kinase A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0007052 [mitotic spindle organization]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0051233 [spindle midzone]
Show all
 106 aa
11.5 kDa 		No 0
AURKA-008
ENSP00000405042
ENST00000422322
Q5QPD2 [Direct mapping]
Aurora kinase A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0007052 [mitotic spindle organization]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0051233 [spindle midzone]
Show all
 147 aa
16.2 kDa 		No 0
AURKA-009
ENSP00000388073
ENST00000420474
A3KFJ1 [Direct mapping]
Aurora kinase A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0051233 [spindle midzone]
Show all
 189 aa
21.2 kDa 		No 0
AURKA-010
ENSP00000379247
ENST00000395911
O14965 [Direct mapping]
Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043146 [spindle stabilization]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-011
ENSP00000379243
ENST00000395907
A3KFJ0 [Direct mapping]
Aurora kinase A
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000212 [meiotic spindle organization]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007100 [mitotic centrosome separation]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0051233 [spindle midzone]
Show all
 347 aa
39.5 kDa 		No 0
AURKA-012
ENSP00000401358
ENST00000451915
A3KFJ2 [Direct mapping]
Aurora kinase A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0007052 [mitotic spindle organization]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0051233 [spindle midzone]
Show all
 79 aa
8.6 kDa 		No 0
AURKA-201
ENSP00000379250
ENST00000395914
O14965 [Direct mapping]
Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043146 [spindle stabilization]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
Show all
 403 aa
45.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.