Fields »
ABOUT
HELP
BLOG
PIR

GENERAL INFORMATION

Gene name

 PIR

Gene description

 Pirin (iron-binding nuclear protein)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA000697
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PIR

Synonyms

Description

 Pirin (iron-binding nuclear protein) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 15384799 - 15493564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087842 (version 83.38)

Entrez gene

 8544

UniProt

 O00625 (UniProt - Evidence at protein level)

neXtProt

 NX_O00625

Antibodypedia

 PIR antibodies

PROTEIN BROWSER
PIR-002
PIR-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIR-002
ENSP00000369785
ENST00000380420
O00625 [Direct mapping]
Pirin
A0A024RBX6 [Target identity:100%; Query identity:100%]
Pirin (Iron-binding nuclear protein), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008127 [quercetin 2,3-dioxygenase activity]
GO:0030224 [monocyte differentiation]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 290 aa
32.1 kDa 		No 0
PIR-003
ENSP00000369786
ENST00000380421
O00625 [Direct mapping]
Pirin
A0A024RBX6 [Target identity:100%; Query identity:100%]
Pirin (Iron-binding nuclear protein), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008127 [quercetin 2,3-dioxygenase activity]
GO:0030099 [myeloid cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 290 aa
32.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.