Tissue expression of ALG6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ALG6
Gene description	ALG6, alpha-1,3-glucosyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ALG6
Synonyms
Description	ALG6, alpha-1,3-glucosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	63367590 - 63438562
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088035 (version 83.38)
Entrez gene	29929
UniProt	Q9Y672 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y672
Antibodypedia	ALG6 antibodies

PROTEIN BROWSER

ALG6-001	ALG6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG6-001 ENSP00000360149 ENST00000371108	Q9Y672 [Direct mapping] Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046527 [glucosyltransferase activity] Show all	507 aa 58.1 kDa	Yes	>9
ALG6-006 ENSP00000263440 ENST00000263440	A2A2G4 [Direct mapping] Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	509 aa 58.3 kDa	Yes	>9