Expression of GP6 in cancer - Summary - The Human Protein Atlas

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GP6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GP6
Gene description	Glycoprotein VI (platelet)
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (HEL, K-562, U-2 OS)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in megakaryocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. RNA-Seq data does not include megakaryocytes.
Reliability score	Approved based on 1 antibody. HPA066482
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA066482

GENE INFORMATION
Gene name	GP6 (HGNC Symbol)
Synonyms	GPVI
Description	Glycoprotein VI (platelet) (HGNC Symbol)
Entrez gene summary	This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	55013705 - 55038264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088053 (version 83.38)
Entrez gene	51206
UniProt	Q9HCN6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCN6
Antibodypedia	GP6 antibodies

PROTEIN BROWSER

GP6-001	GP6-002	GP6-003	GP6-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GP6-001 ENSP00000394922 ENST00000417454	Q9HCN6 [Direct mapping] Platelet glycoprotein VI Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0030168 [platelet activation] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0097197 [tetraspanin-enriched microdomain] Show all	339 aa 36.9 kDa	Yes	1
GP6-002 ENSP00000308782 ENST00000310373	Q9HCN6 [Direct mapping] Platelet glycoprotein VI Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0030168 [platelet activation] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0097197 [tetraspanin-enriched microdomain] Show all	620 aa 67.5 kDa	Yes	0
GP6-003 ENSP00000334552 ENST00000333884	Q9HCN6 [Direct mapping] Platelet glycoprotein VI Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0030168 [platelet activation] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0097197 [tetraspanin-enriched microdomain] Show all	321 aa 35.1 kDa	Yes	1
GP6-005 ENSP00000464922 ENST00000468239	K7EIW7 [Direct mapping] Platelet glycoprotein VI Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	117 aa 13 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.