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GNA11

GENERAL INFORMATION

Gene name

 GNA11

Gene description

 Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membrane and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA048886
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GNA11 (HGNC Symbol)

Synonyms

 FBH, FBH2, FHH2, HHC2

Description

 Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 3094410 - 3124004

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088256 (version 83.38)

Entrez gene

 2767

UniProt

 P29992 (UniProt - Evidence at protein level)

neXtProt

 NX_P29992

Antibodypedia

 GNA11 antibodies

PROTEIN BROWSER
GNA11-001
GNA11-003
GNA11-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNA11-001
ENSP00000078429
ENST00000078429
P29992 [Direct mapping]
Guanine nucleotide-binding protein subunit alpha-11
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001508 [action potential]
GO:0001750 [photoreceptor outer segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008152 [metabolic process]
GO:0009649 [entrainment of circadian clock]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031826 [type 2A serotonin receptor binding]
GO:0045634 [regulation of melanocyte differentiation]
GO:0046872 [metal ion binding]
GO:0048066 [developmental pigmentation]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071467 [cellular response to pH]
Show all
 359 aa
42.1 kDa 		No 0
GNA11-003
ENSP00000479797
ENST00000588401
A0A087WVZ3 [Direct mapping]
Guanine nucleotide-binding protein subunit alpha-11
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001508 [action potential]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031826 [type 2A serotonin receptor binding]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
Show all
 72 aa
8 kDa 		No 0
GNA11-007
ENSP00000465935
ENST00000587636
K7EL62 [Direct mapping]
Guanine nucleotide-binding protein subunit alpha-11
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001508 [action potential]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031826 [type 2A serotonin receptor binding]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
Show all
 236 aa
27.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.