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Most cancer cells showed weak to moderate cytoplasmic positivity. Several cases of melanomas, colorectal and lung cancers exhibited strong staining. A majority of renal cell carcinomas were negative.
GENE INFORMATION
Gene name
EDEM2 (HGNC Symbol)
Synonyms
bA4204.1, C20orf31, C20orf49, FLJ10783
Description
ER degradation enhancer, mannosidase alpha-like 2 (HGNC Symbol)
Entrez gene summary
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]