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DNMT3B

GENERAL INFORMATION

Gene name

 DNMT3B

Gene description

 DNA (cytosine-5-)-methyltransferase 3 beta

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression, most abundant in testis and placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 2 antibodies.
HPA001595 , CAB069896
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001595
CAB069896

GENE INFORMATION

Gene name

 DNMT3B

Synonyms

Description

 DNA (cytosine-5-)-methyltransferase 3 beta (HGNC Symbol)

Entrez gene summary

 CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 32762385 - 32809356

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088305 (version 83.38)

Entrez gene

 1789

UniProt

 Q9UBC3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBC3

Antibodypedia

 DNMT3B antibodies

PROTEIN BROWSER
DNMT3B-001
DNMT3B-002
DNMT3B-003
DNMT3B-004
DNMT3B-005
DNMT3B-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNMT3B-001
ENSP00000328547
ENST00000328111
Q9UBC3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3B
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000792 [heterochromatin]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0003886 [DNA (cytosine-5-)-methyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005737 [cytoplasm]
GO:0006306 [DNA methylation]
GO:0006346 [methylation-dependent chromatin silencing]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0008168 [methyltransferase activity]
GO:0009008 [DNA-methyltransferase activity]
GO:0009636 [response to toxic substance]
GO:0010212 [response to ionizing radiation]
GO:0010424 [DNA methylation on cytosine within a CG sequence]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0014823 [response to activity]
GO:0031000 [response to caffeine]
GO:0031503 [protein complex localization]
GO:0032355 [response to estradiol]
GO:0032776 [DNA methylation on cytosine]
GO:0033189 [response to vitamin A]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045322 [unmethylated CpG binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046498 [S-adenosylhomocysteine metabolic process]
GO:0046499 [S-adenosylmethioninamine metabolic process]
GO:0046872 [metal ion binding]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051573 [negative regulation of histone H3-K9 methylation]
GO:0051718 [DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates]
GO:0060821 [inactivation of X chromosome by DNA methylation]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0090116 [C-5 methylation of cytosine]
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 853 aa
95.8 kDa 		No 0
DNMT3B-002
ENSP00000313397
ENST00000353855
Q9UBC3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0003886 [DNA (cytosine-5-)-methyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0008168 [methyltransferase activity]
GO:0009008 [DNA-methyltransferase activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051573 [negative regulation of histone H3-K9 methylation]
GO:0090116 [C-5 methylation of cytosine]
Show all
 833 aa
93.4 kDa 		No 0
DNMT3B-003
ENSP00000337764
ENST00000348286
Q9UBC3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0003886 [DNA (cytosine-5-)-methyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0008168 [methyltransferase activity]
GO:0009008 [DNA-methyltransferase activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051573 [negative regulation of histone H3-K9 methylation]
GO:0090116 [C-5 methylation of cytosine]
Show all
 770 aa
86.2 kDa 		No 0
DNMT3B-004
ENSP00000201963
ENST00000201963
Q9UBC3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0003886 [DNA (cytosine-5-)-methyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0008168 [methyltransferase activity]
GO:0009008 [DNA-methyltransferase activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051573 [negative regulation of histone H3-K9 methylation]
GO:0090116 [C-5 methylation of cytosine]
Show all
 845 aa
94.7 kDa 		No 0
DNMT3B-005
ENSP00000412305
ENST00000456297
Q9UBC3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0003886 [DNA (cytosine-5-)-methyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0008168 [methyltransferase activity]
GO:0009008 [DNA-methyltransferase activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051573 [negative regulation of histone H3-K9 methylation]
GO:0090116 [C-5 methylation of cytosine]
Show all
 694 aa
77.7 kDa 		No 0
DNMT3B-006
ENSP00000403169
ENST00000443239
Q9UBC3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0003886 [DNA (cytosine-5-)-methyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0008168 [methyltransferase activity]
GO:0009008 [DNA-methyltransferase activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051573 [negative regulation of histone H3-K9 methylation]
GO:0090116 [C-5 methylation of cytosine]
Show all
 728 aa
81.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.