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REM1

GENERAL INFORMATION

Gene name

 REM1

Gene description

 RAS (RAD and GEM)-like GTP-binding 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (WM-115)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, highly expressed in endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA049821
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049821

GENE INFORMATION

Gene name

 REM1 (HGNC Symbol)

Synonyms

 GES, REM

Description

 RAS (RAD and GEM)-like GTP-binding 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31475293 - 31484905

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088320 (version 83.38)

Entrez gene

 28954

UniProt

 O75628 (UniProt - Evidence at protein level)

neXtProt

 NX_O75628

Antibodypedia

 REM1 antibodies

PROTEIN BROWSER
REM1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REM1-001
ENSP00000201979
ENST00000201979
O75628 [Direct mapping]
GTP-binding protein REM 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005516 [calmodulin binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
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 298 aa
32.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.