Expression of ANKRD10 in cancer - Summary - The Human Protein Atlas

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ANKRD10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKRD10
Gene description	Ankyrin repeat domain 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA038878 , HPA038879 , CAB034211
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038878	HPA038879	CAB034211

GENE INFORMATION
Gene name	ANKRD10 (HGNC Symbol)
Synonyms	FLJ20093
Description	Ankyrin repeat domain 10 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q34
Chromosome location (bp)	110878540 - 110915069
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088448 (version 83.38)
Entrez gene	55608
UniProt	Q9NXR5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NXR5
Antibodypedia	ANKRD10 antibodies

PROTEIN BROWSER

ANKRD10-003	ANKRD10-004	ANKRD10-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD10-003 ENSP00000267339 ENST00000267339	Q9NXR5 [Direct mapping] Ankyrin repeat domain-containing protein 10 A0A024RE01 [Target identity:100%; Query identity:100%] Ankyrin repeat domain 10, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0060828 [regulation of canonical Wnt signaling pathway] Show all	420 aa 44.8 kDa	No	0
ANKRD10-004 ENSP00000312534 ENST00000310847	Q9NXR5 [Direct mapping] Ankyrin repeat domain-containing protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0060828 [regulation of canonical Wnt signaling pathway] Show all	220 aa 23.5 kDa	No	0
ANKRD10-011 ENSP00000474638 ENST00000603993	S4R3R2 [Direct mapping] Ankyrin repeat domain-containing protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0060828 [regulation of canonical Wnt signaling pathway] Show all	121 aa 13.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.