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NSFL1C

GENERAL INFORMATION

Gene name

 NSFL1C

Gene description

 NSFL1 (p97) cofactor (p47)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA047108 , HPA050628
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047108
HPA050628

GENE INFORMATION

Gene name

 NSFL1C (HGNC Symbol)

Synonyms

 dJ776F14.1, p47, UBX1, UBXD10, UBXN2C

Description

 NSFL1 (p97) cofactor (p47) (HGNC Symbol)

Entrez gene summary

 N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 1442162 - 1473842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088833 (version 83.38)

Entrez gene

 55968

UniProt

 Q9UNZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNZ2

Antibodypedia

 NSFL1C antibodies

PROTEIN BROWSER
NSFL1C-002
NSFL1C-004
NSFL1C-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NSFL1C-002
ENSP00000216879
ENST00000216879
Q9UNZ2 [Direct mapping]
NSFL1 cofactor p47
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000045 [autophagosome assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005795 [Golgi stack]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007030 [Golgi organization]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031468 [nuclear envelope reassembly]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0050790 [regulation of catalytic activity]
GO:0061025 [membrane fusion]
GO:1990730 [VCP-NSFL1C complex]
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 370 aa
40.6 kDa 		No 0
NSFL1C-004
ENSP00000338643
ENST00000353088
Q9UNZ2 [Direct mapping]
NSFL1 cofactor p47
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005795 [Golgi stack]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007030 [Golgi organization]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031468 [nuclear envelope reassembly]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0050790 [regulation of catalytic activity]
GO:0061025 [membrane fusion]
GO:1990730 [VCP-NSFL1C complex]
Show all
 339 aa
37.3 kDa 		No 0
NSFL1C-010
ENSP00000418529
ENST00000476071
Q9UNZ2 [Direct mapping]
NSFL1 cofactor p47
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005795 [Golgi stack]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007030 [Golgi organization]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031468 [nuclear envelope reassembly]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0050790 [regulation of catalytic activity]
GO:0051117 [ATPase binding]
GO:0061025 [membrane fusion]
GO:1990730 [VCP-NSFL1C complex]
Show all
 372 aa
40.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.