Expression of RP5-1187M17.10 in cancer - Summary - The Human Protein Atlas

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RP5-1187M17.10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RP5-1187M17.10
Gene description	Leucine zipper putative tumor suppressor 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and often membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA031008 , HPA031009
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (unfavourable) and lung cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031008	HPA031009

GENE INFORMATION
Gene name	RP5-1187M17.10
Synonyms
Description	Leucine zipper putative tumor suppressor 3 (UniProtKB/Swiss-Prot)
Entrez gene summary
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3162617 - 3173592
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088899 (version 83.38)
Entrez gene	9762
UniProt	O60299 (UniProt - Evidence at transcript level)
neXtProt	NX_O60299
Antibodypedia	RP5-1187M17.10 antibodies

PROTEIN BROWSER

RP5-1187M17.10-001	RP5-1187M17.10-002	RP5-1187M17.10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RP5-1187M17.10-001 ENSP00000332123 ENST00000329152	O60299 [Target identity:100%; Query identity:100%] Leucine zipper putative tumor suppressor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] Show all	673 aa 71.8 kDa	No	0
RP5-1187M17.10-002 ENSP00000353496 ENST00000360342		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		627 aa 66.4 kDa	No	0
RP5-1187M17.10-201 ENSP00000338166 ENST00000337576	O60299 [Target identity:100%; Query identity:100%] Leucine zipper putative tumor suppressor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] Show all	673 aa 71.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.