Expression of F11 in cancer - Summary - The Human Protein Atlas

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F11

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	F11
Gene description	Coagulation factor XI
Protein class	Candidate cardiovascular disease genes Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	F11 (HGNC Symbol)
Synonyms	FXI
Description	Coagulation factor XI (HGNC Symbol)
Entrez gene summary	This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q35.2
Chromosome location (bp)	186265945 - 186288806
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088926 (version 83.38)
Entrez gene	2160
UniProt	P03951 (UniProt - Evidence at protein level)
neXtProt	NX_P03951
Antibodypedia	F11 antibodies

PROTEIN BROWSER

F11-001	F11-002	F11-003	F11-007	F11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
F11-001 ENSP00000384957 ENST00000403665	P03951 [Direct mapping] Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0007597 [blood coagulation, intrinsic pathway] GO:0008201 [heparin binding] GO:0016020 [membrane] GO:0030193 [regulation of blood coagulation] GO:0031639 [plasminogen activation] GO:0051919 [positive regulation of fibrinolysis] GO:0070009 [serine-type aminopeptidase activity] GO:0070062 [extracellular exosome] Show all	625 aa 70.1 kDa	Yes	0
F11-002 ENSP00000424479 ENST00000492972	D6RB32 [Direct mapping] Coagulation factor XI Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	162 aa 18.5 kDa	Yes	0
F11-003 ENSP00000397401 ENST00000452239	H0Y596 [Direct mapping] Coagulation factor XI Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	210 aa 23 kDa	No	0
F11-007 ENSP00000264691 ENST00000264691	X6R3B1 [Direct mapping] Coagulation factor XI Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	159 aa 17.9 kDa	No	0
F11-201 ENSP00000264692 ENST00000264692	P03951 [Direct mapping] Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0007597 [blood coagulation, intrinsic pathway] GO:0008201 [heparin binding] GO:0016020 [membrane] GO:0031639 [plasminogen activation] GO:0051919 [positive regulation of fibrinolysis] GO:0070062 [extracellular exosome] Show all	571 aa 63.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.