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F11
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

F11

Gene description

Coagulation factor XI

Protein class

Candidate cardiovascular disease genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enhanced (liver)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

F11 (HGNC Symbol)

Synonyms

FXI

Description

Coagulation factor XI (HGNC Symbol)

Entrez gene summary

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q35.2

Chromosome location (bp)

186265945 - 186288806

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000088926 (version 83.38)

Entrez gene

2160

UniProt

P03951 (UniProt - Evidence at protein level)

neXtProt

NX_P03951

Antibodypedia

F11 antibodies

PROTEIN BROWSER

F11-001
F11-002
F11-003
F11-007
F11-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F11-001
ENSP00000384957
ENST00000403665
P03951 [Direct mapping]
Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008201 [heparin binding]
GO:0016020 [membrane]
GO:0030193 [regulation of blood coagulation]
GO:0031639 [plasminogen activation]
GO:0051919 [positive regulation of fibrinolysis]
GO:0070009 [serine-type aminopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
625 aa
70.1 kDa
Yes 0
F11-002
ENSP00000424479
ENST00000492972
D6RB32 [Direct mapping]
Coagulation factor XI
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
Show all
162 aa
18.5 kDa
Yes 0
F11-003
ENSP00000397401
ENST00000452239
H0Y596 [Direct mapping]
Coagulation factor XI
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
Show all
210 aa
23 kDa
No 0
F11-007
ENSP00000264691
ENST00000264691
X6R3B1 [Direct mapping]
Coagulation factor XI
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
159 aa
17.9 kDa
No 0
F11-201
ENSP00000264692
ENST00000264692
P03951 [Direct mapping]
Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008201 [heparin binding]
GO:0016020 [membrane]
GO:0031639 [plasminogen activation]
GO:0051919 [positive regulation of fibrinolysis]
GO:0070062 [extracellular exosome]
Show all
571 aa
63.8 kDa
Yes 0

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