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DYNLL1

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GENERAL INFORMATION

Gene name

 DYNLL1

Gene description

 Dynein, light chain, LC8-type 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & nucleoplasm. In addition localized to the nuclear bodies. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Cytosol (approved)

Additional location

 In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA039954
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & nucleoplasm. In addition localized to the nuclear bodies. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleoplasm (approved), Cytosol (approved)

Additional location

 Nuclear bodies (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039954 MCF7 Nucleoplasm
Cytosol
HPA039954 PC-3 Nucleoplasm
Nuclear bodies
Cytosol
HPA039954 U-2 OS Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 DYNLL1 (HGNC Symbol)

Synonyms

 DLC1, DLC8, DNCL1, hdlc1, LC8, PIN

Description

 Dynein, light chain, LC8-type 1 (HGNC Symbol)

Entrez gene summary

 Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 120469850 - 120498493

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088986 (version 83.38)

Entrez gene

 8655

UniProt

 P63167 (UniProt - Evidence at protein level)

neXtProt

 NX_P63167

Antibodypedia

 DYNLL1 antibodies

PROTEIN BROWSER
DYNLL1-001
DYNLL1-002
DYNLL1-003
DYNLL1-004
DYNLL1-005
DYNLL1-006
DYNLL1-007
DYNLL1-008
DYNLL1-009
DYNLL1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYNLL1-001
ENSP00000242577
ENST00000242577
P63167 [Direct mapping]
Dynein light chain 1, cytoplasmic
Q6FGH9 [Target identity:100%; Query identity:100%]
DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007292 [female gamete generation]
GO:0008180 [COP9 signalosome]
GO:0009653 [anatomical structure morphogenesis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0042326 [negative regulation of phosphorylation]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0072686 [mitotic spindle]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097542 [ciliary tip]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 89 aa
10.4 kDa 		No 0
DYNLL1-002
ENSP00000447494
ENST00000550845
F8VRV5 [Direct mapping]
Dynein light chain 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005875 [microtubule associated complex]
GO:0007017 [microtubule-based process]
Show all
 67 aa
7.2 kDa 		No 0
DYNLL1-003
ENSP00000376296
ENST00000392508
P63167 [Direct mapping]
Dynein light chain 1, cytoplasmic
Q6FGH9 [Target identity:100%; Query identity:100%]
DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007292 [female gamete generation]
GO:0008180 [COP9 signalosome]
GO:0009653 [anatomical structure morphogenesis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0042326 [negative regulation of phosphorylation]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0072686 [mitotic spindle]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097542 [ciliary tip]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 89 aa
10.4 kDa 		No 0
DYNLL1-004
ENSP00000447907
ENST00000548342
P63167 [Direct mapping]
Dynein light chain 1, cytoplasmic
Q6FGH9 [Target identity:100%; Query identity:100%]
DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007292 [female gamete generation]
GO:0008180 [COP9 signalosome]
GO:0009653 [anatomical structure morphogenesis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0042326 [negative regulation of phosphorylation]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0072686 [mitotic spindle]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097542 [ciliary tip]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 89 aa
10.4 kDa 		No 0
DYNLL1-005
ENSP00000448834
ENST00000549649
F8VXI7 [Direct mapping]
Dynein light chain 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005875 [microtubule associated complex]
GO:0007017 [microtubule-based process]
Show all
 42 aa
4.8 kDa 		No 0
DYNLL1-006
ENSP00000376297
ENST00000392509
P63167 [Direct mapping]
Dynein light chain 1, cytoplasmic
Q6FGH9 [Target identity:100%; Query identity:100%]
DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007292 [female gamete generation]
GO:0008022 [protein C-terminus binding]
GO:0008180 [COP9 signalosome]
GO:0009653 [anatomical structure morphogenesis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0035721 [intraciliary retrograde transport]
GO:0042326 [negative regulation of phosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0050790 [regulation of catalytic activity]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0072686 [mitotic spindle]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097542 [ciliary tip]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 89 aa
10.4 kDa 		No 0
DYNLL1-007
ENSP00000448608
ENST00000548214
F8VRV5 [Direct mapping]
Dynein light chain 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005875 [microtubule associated complex]
GO:0007017 [microtubule-based process]
Show all
 67 aa
7.2 kDa 		No 0
DYNLL1-008
ENSP00000446614
ENST00000549989
P63167 [Direct mapping]
Dynein light chain 1, cytoplasmic
Q6FGH9 [Target identity:100%; Query identity:100%]
DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007292 [female gamete generation]
GO:0008180 [COP9 signalosome]
GO:0009653 [anatomical structure morphogenesis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0042326 [negative regulation of phosphorylation]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0072686 [mitotic spindle]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097542 [ciliary tip]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 89 aa
10.4 kDa 		No 0
DYNLL1-009
ENSP00000449088
ENST00000552870
F8VXL2 [Direct mapping]
Dynein light chain 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005875 [microtubule associated complex]
GO:0007017 [microtubule-based process]
Show all
 47 aa
5.4 kDa 		No 0
DYNLL1-010
ENSP00000446596
ENST00000550178
F8VRV5 [Direct mapping]
Dynein light chain 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005875 [microtubule associated complex]
GO:0007017 [microtubule-based process]
Show all
 67 aa
7.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.