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SNX5

GENERAL INFORMATION

Gene name

 SNX5

Gene description

 Sorting nexin 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA051187 , CAB020679
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051187
CAB020679

GENE INFORMATION

Gene name

 SNX5

Synonyms

Description

 Sorting nexin 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

Chromosome

 20

Cytoband

 p11.23

Chromosome location (bp)

 17941597 - 17968980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089006 (version 83.38)

Entrez gene

 27131

UniProt

 Q9Y5X3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5X3

Antibodypedia

 SNX5 antibodies

PROTEIN BROWSER
SNX5-001
SNX5-003
SNX5-006
SNX5-012
SNX5-013
SNX5-014
SNX5-017
SNX5-018
SNX5-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX5-001
ENSP00000366998
ENST00000377768
Q9Y5X3 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001891 [phagocytic cup]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006907 [pinocytosis]
GO:0016050 [vesicle organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031313 [extrinsic component of endosome membrane]
GO:0031901 [early endosome membrane]
GO:0034452 [dynactin binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0046982 [protein heterodimerization activity]
GO:0070685 [macropinocytic cup]
GO:0097422 [tubular endosome]
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 404 aa
46.8 kDa 		No 0
SNX5-003
ENSP00000475606
ENST00000481323
U3KQL0 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005768 [endosome]
GO:0016050 [vesicle organization]
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 31 aa
3.5 kDa 		No 0
SNX5-006
ENSP00000475983
ENST00000486039
U3KQL0 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0016050 [vesicle organization]
Show all
 31 aa
3.5 kDa 		No 0
SNX5-012
ENSP00000406731
ENST00000419004
Q5QPE4 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006907 [pinocytosis]
GO:0016050 [vesicle organization]
GO:0035091 [phosphatidylinositol binding]
Show all
 231 aa
26.7 kDa 		No 0
SNX5-013
ENSP00000404448
ENST00000431277
Q5QPE5 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006907 [pinocytosis]
GO:0016050 [vesicle organization]
GO:0035091 [phosphatidylinositol binding]
Show all
 269 aa
31 kDa 		No 0
SNX5-014
ENSP00000479021
ENST00000463050
A0A087WUY5 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006907 [pinocytosis]
GO:0016050 [vesicle organization]
GO:0035091 [phosphatidylinositol binding]
Show all
 170 aa
19.6 kDa 		No 0
SNX5-017
ENSP00000476097
ENST00000606602
U3KQP5 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0016050 [vesicle organization]
Show all
 55 aa
5.9 kDa 		No 0
SNX5-018
ENSP00000475510
ENST00000606557
Q9Y5X3 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001891 [phagocytic cup]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006907 [pinocytosis]
GO:0016050 [vesicle organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031313 [extrinsic component of endosome membrane]
GO:0031901 [early endosome membrane]
GO:0034452 [dynactin binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0046982 [protein heterodimerization activity]
GO:0070685 [macropinocytic cup]
GO:0097422 [tubular endosome]
Show all
 126 aa
13.3 kDa 		No 0
SNX5-019
ENSP00000366988
ENST00000377759
Q9Y5X3 [Direct mapping]
Sorting nexin-5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001891 [phagocytic cup]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006907 [pinocytosis]
GO:0016050 [vesicle organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031313 [extrinsic component of endosome membrane]
GO:0031901 [early endosome membrane]
GO:0034452 [dynactin binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0046982 [protein heterodimerization activity]
GO:0070685 [macropinocytic cup]
GO:0097422 [tubular endosome]
Show all
 404 aa
46.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.