Tissue expression of SIRPG - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SIRPG
Gene description	Signal-regulatory protein gamma
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node, tonsil)
GTEx:	Group enriched (small intestine, spleen, testis)
FANTOM5:	Tissue enhanced (appendix, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (small intestine, spleen, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION
Gene name	SIRPG (HGNC Symbol)
Synonyms	bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPgamma
Description	Signal-regulatory protein gamma (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	1629152 - 1657779
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089012 (version 83.38)
Entrez gene	55423
UniProt	Q9P1W8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P1W8
Antibodypedia	SIRPG antibodies

PROTEIN BROWSER

SIRPG-001	SIRPG-004	SIRPG-005	SIRPG-006	SIRPG-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIRPG-001 ENSP00000370992 ENST00000381580	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	354 aa 39 kDa	No	1
SIRPG-004 ENSP00000342759 ENST00000344103	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	170 aa 18.5 kDa	Yes	1
SIRPG-005 ENSP00000305529 ENST00000303415	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	387 aa 42.5 kDa	Yes	1
SIRPG-006 ENSP00000216927 ENST00000216927	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	276 aa 30 kDa	Yes	1
SIRPG-201 ENSP00000370995 ENST00000381583	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	276 aa 30 kDa	Yes	1