Expression of DZANK1 in cancer - Summary - The Human Protein Atlas

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DZANK1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DZANK1
Gene description	Double zinc ribbon and ankyrin repeat domains 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (THP-1, U-266/84)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA059478
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059478

GENE INFORMATION
Gene name	DZANK1 (HGNC Symbol)
Synonyms	ANKRD64, bA189K21.8, C20orf12, C20orf84, dJ568F9.2, FLJ10600, FLJ30892
Description	Double zinc ribbon and ankyrin repeat domains 1 (HGNC Symbol)
Entrez gene summary	This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. Alternative splicing has been observed for this gene but the full-length nature of additional variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p11.23
Chromosome location (bp)	18383367 - 18467281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089091 (version 83.38)
Entrez gene	55184
UniProt	Q9NVP4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVP4
Antibodypedia	DZANK1 antibodies

PROTEIN BROWSER

DZANK1-002	DZANK1-006	DZANK1-007	DZANK1-011	DZANK1-201	DZANK1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DZANK1-002 ENSP00000349774 ENST00000357236	A0A0A0MRE2 [Direct mapping] Double zinc ribbon and ankyrin repeat-containing protein 1 Show all	Predicted intracellular proteins Show all		559 aa 60.9 kDa	No	0
DZANK1-006 ENSP00000484666 ENST00000480488	A0A087X236 [Direct mapping] Double zinc ribbon and ankyrin repeat-containing protein 1 Show all	Predicted intracellular proteins Show all		140 aa 15.8 kDa	No	0
DZANK1-007 ENSP00000479439 ENST00000476058	A0A087WVH4 [Direct mapping] Double zinc ribbon and ankyrin repeat-containing protein 1 Show all	Predicted intracellular proteins Show all		225 aa 24.3 kDa	No	0
DZANK1-011 ENSP00000351734 ENST00000358866	Q9NVP4 [Direct mapping] Double zinc ribbon and ankyrin repeat-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	752 aa 82.2 kDa	No	0
DZANK1-201 ENSP00000262547 ENST00000262547	Q9NVP4 [Direct mapping] Double zinc ribbon and ankyrin repeat-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	752 aa 82.2 kDa	No	0
DZANK1-202 ENSP00000328866 ENST00000329494	C9J2A8 [Direct mapping] Double zinc ribbon and ankyrin repeat-containing protein 1 Show all	Predicted intracellular proteins Show all		462 aa 50.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.