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KDM2B

GENERAL INFORMATION

Gene name

 KDM2B

Gene description

 Lysine (K)-specific demethylase 2B

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and pancreatic cancer (favourable).
Head and neck cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KDM2B (HGNC Symbol)

Synonyms

 CXXC2, Fbl10, FBXL10, JHDM1B, PCCX2

Description

 Lysine (K)-specific demethylase 2B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 121429097 - 121581015

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089094 (version 83.38)

Entrez gene

 84678

UniProt

 Q8NHM5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NHM5

Antibodypedia

 KDM2B antibodies

PROTEIN BROWSER
«
KDM2B-001
KDM2B-004
KDM2B-005
KDM2B-006
KDM2B-007
KDM2B-011
KDM2B-012
KDM2B-014
KDM2B-015
KDM2B-016
KDM2B-017
KDM2B-022
KDM2B-201
KDM2B-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KDM2B-001
ENSP00000366271
ENST00000377071
Q8NHM5 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0016577 [histone demethylation]
GO:0019843 [rRNA binding]
GO:0021555 [midbrain-hindbrain boundary morphogenesis]
GO:0021592 [fourth ventricle development]
GO:0021670 [lateral ventricle development]
GO:0021678 [third ventricle development]
GO:0021993 [initiation of neural tube closure]
GO:0030307 [positive regulation of cell growth]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0031519 [PcG protein complex]
GO:0032452 [histone demethylase activity]
GO:0035518 [histone H2A monoubiquitination]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0070544 [histone H3-K36 demethylation]
GO:1902459 [positive regulation of stem cell population maintenance]
GO:2000178 [negative regulation of neural precursor cell proliferation]
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 1336 aa
152.6 kDa 		No 0
KDM2B-004
ENSP00000474307
ENST00000538046
S4R3G4 [Direct mapping]
Lysine-specific demethylase 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 507 aa
58.1 kDa 		No 0
KDM2B-005
ENSP00000366269
ENST00000377069
Q8NHM5 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0016577 [histone demethylation]
GO:0019843 [rRNA binding]
GO:0021555 [midbrain-hindbrain boundary morphogenesis]
GO:0021592 [fourth ventricle development]
GO:0021670 [lateral ventricle development]
GO:0021678 [third ventricle development]
GO:0021993 [initiation of neural tube closure]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0031519 [PcG protein complex]
GO:0032452 [histone demethylase activity]
GO:0035518 [histone H2A monoubiquitination]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0070544 [histone H3-K36 demethylation]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 1265 aa
144.8 kDa 		No 0
KDM2B-006
ENSP00000398279
ENST00000446152
F8WBN2 [Direct mapping]
Lysine-specific demethylase 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 510 aa
59.2 kDa 		No 0
KDM2B-007
ENSP00000440373
ENST00000539394
F5GXC2 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 180 aa
21.1 kDa 		No 0
KDM2B-011
ENSP00000440942
ENST00000543852
F5GXW2 [Direct mapping]
Lysine-specific demethylase 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 123 aa
14.4 kDa 		No 0
KDM2B-012
ENSP00000442293
ENST00000541511
F5H7T7 [Direct mapping]
Lysine-specific demethylase 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 97 aa
11.1 kDa 		No 0
KDM2B-014
ENSP00000443052
ENST00000541318
F5H5W7 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 41 aa
4.6 kDa 		No 0
KDM2B-015
ENSP00000445102
ENST00000538379
F5H4A7 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 171 aa
20.4 kDa 		No 0
KDM2B-016
ENSP00000437497
ENST00000545022
F5H6N6 [Direct mapping]
Lysine-specific demethylase 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 154 aa
18.5 kDa 		No 0
KDM2B-017
ENSP00000444846
ENST00000542030
F5H4X4 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
15.1 kDa 		No 0
KDM2B-022
ENSP00000437821
ENST00000542973
A0A0C4DGG3 [Direct mapping]
Lysine-specific demethylase 2B
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 704 aa
80 kDa 		No 0
KDM2B-201
ENSP00000445196
ENST00000536437
F6SRV7 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
 706 aa
80.7 kDa 		No 0
KDM2B-202
ENSP00000480847
ENST00000611216
Q8NHM5 [Direct mapping]
Lysine-specific demethylase 2B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0016577 [histone demethylation]
GO:0019843 [rRNA binding]
GO:0021555 [midbrain-hindbrain boundary morphogenesis]
GO:0021592 [fourth ventricle development]
GO:0021670 [lateral ventricle development]
GO:0021678 [third ventricle development]
GO:0021993 [initiation of neural tube closure]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0031519 [PcG protein complex]
GO:0032452 [histone demethylase activity]
GO:0035518 [histone H2A monoubiquitination]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0070544 [histone H3-K36 demethylation]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 559 aa
63.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.