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OAS1

GENERAL INFORMATION

Gene name

 OAS1

Gene description

 2'-5'-oligoadenylate synthetase 1, 40/46kDa

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, U-266/70, U-266/84)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA003657 , CAB021104
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and pancreatic cancer (unfavourable).
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003657
CAB021104

GENE INFORMATION

Gene name

 OAS1 (HGNC Symbol)

Synonyms

 IFI-4, OIAS, OIASI

Description

 2'-5'-oligoadenylate synthetase 1, 40/46kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.13

Chromosome location (bp)

 112906777 - 112933222

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089127 (version 83.38)

Entrez gene

 4938

UniProt

 P00973 (UniProt - Evidence at protein level)

neXtProt

 NX_P00973

Antibodypedia

 OAS1 antibodies

PROTEIN BROWSER
OAS1-001
OAS1-002
OAS1-003
OAS1-005
OAS1-006
OAS1-007
OAS1-009
OAS1-010
OAS1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OAS1-001
ENSP00000202917
ENST00000202917
P00973 [Direct mapping]
2'-5'-oligoadenylate synthase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001730 [2'-5'-oligoadenylate synthetase activity]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0009615 [response to virus]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035457 [cellular response to interferon-alpha]
GO:0042593 [glucose homeostasis]
GO:0045071 [negative regulation of viral genome replication]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060700 [regulation of ribonuclease activity]
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 400 aa
46 kDa 		No 0
OAS1-002
ENSP00000415721
ENST00000452357
P00973 [Direct mapping]
2'-5'-oligoadenylate synthase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001730 [2'-5'-oligoadenylate synthetase activity]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0009615 [response to virus]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035457 [cellular response to interferon-alpha]
GO:0042593 [glucose homeostasis]
GO:0045071 [negative regulation of viral genome replication]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060700 [regulation of ribonuclease activity]
Show all
 364 aa
41.7 kDa 		No 0
OAS1-003
ENSP00000388001
ENST00000445409
P00973 [Direct mapping]
2'-5'-oligoadenylate synthase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001730 [2'-5'-oligoadenylate synthetase activity]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0009615 [response to virus]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035457 [cellular response to interferon-alpha]
GO:0042593 [glucose homeostasis]
GO:0045071 [negative regulation of viral genome replication]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060700 [regulation of ribonuclease activity]
Show all
 414 aa
47.4 kDa 		No 0
OAS1-005
ENSP00000448348
ENST00000550689
H0YI20 [Direct mapping]
2'-5'-oligoadenylate synthase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0051607 [defense response to virus]
Show all
 302 aa
35.1 kDa 		No 0
OAS1-006
ENSP00000448790
ENST00000551241
F8VXY3 [Direct mapping]
2'-5'-oligoadenylate synthase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0051607 [defense response to virus]
Show all
 360 aa
41.5 kDa 		No 0
OAS1-007
ENSP00000475139
ENST00000552526
C6EMZ7 [Direct mapping]
2'-5' oligoadenylate synthetase 1 p41 isoform; 2'-5'-oligoadenylate synthase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 15 aa
1.7 kDa 		No 0
OAS1-009
ENSP00000448001
ENST00000553185
F8VUC8 [Direct mapping]
2'-5'-oligoadenylate synthase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0051607 [defense response to virus]
Show all
 177 aa
19.9 kDa 		No 0
OAS1-010
ENSP00000450286
ENST00000550883
F8VPW7 [Direct mapping]
2'-5'-oligoadenylate synthase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0051607 [defense response to virus]
Show all
 83 aa
9.6 kDa 		No 0
OAS1-011
ENSP00000449053
ENST00000553152
H0YIB8 [Direct mapping]
2'-5'-oligoadenylate synthase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005524 [ATP binding]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0051607 [defense response to virus]
Show all
 130 aa
15.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.