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PXN

GENERAL INFORMATION

Gene name

 PXN

Gene description

 Paxillin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB003841
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable), glioma (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Head and neck cancer p<0.001
Glioma p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB003841

GENE INFORMATION

Gene name

 PXN

Synonyms

Description

 Paxillin (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q24.23

Chromosome location (bp)

 120210439 - 120265771

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089159 (version 83.38)

Entrez gene

 5829

UniProt

 P49023 (UniProt - Evidence at protein level)

neXtProt

 NX_P49023

Antibodypedia

 PXN antibodies

PROTEIN BROWSER
PXN-001
PXN-002
PXN-003
PXN-004
PXN-009
PXN-012
PXN-013
PXN-014
PXN-015
PXN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PXN-001
ENSP00000228307
ENST00000228307
P49023 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0034329 [cell junction assembly]
GO:0034614 [cellular response to reactive oxygen species]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
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 591 aa
64.5 kDa 		No 0
PXN-002
ENSP00000391283
ENST00000424649
P49023 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0034329 [cell junction assembly]
GO:0034614 [cellular response to reactive oxygen species]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
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 557 aa
61 kDa 		No 0
PXN-003
ENSP00000395536
ENST00000458477
P49023 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0034329 [cell junction assembly]
GO:0034614 [cellular response to reactive oxygen species]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
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 424 aa
46.6 kDa 		No 0
PXN-004
ENSP00000443887
ENST00000536957
F5GZ78 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0008270 [zinc ion binding]
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 589 aa
64.2 kDa 		No 0
PXN-009
ENSP00000443745
ENST00000543331
F5H836 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007160 [cell-matrix adhesion]
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 177 aa
18.8 kDa 		No 0
PXN-012
ENSP00000446607
ENST00000548912
F8W0G0 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
GO:0007160 [cell-matrix adhesion]
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 36 aa
3.8 kDa 		No 0
PXN-013
ENSP00000447180
ENST00000546532
F8W0K8 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
GO:0007160 [cell-matrix adhesion]
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 37 aa
3.9 kDa 		No 0
PXN-014
ENSP00000446650
ENST00000552550
F8W1E0 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
GO:0007160 [cell-matrix adhesion]
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 31 aa
3.3 kDa 		No 0
PXN-015
ENSP00000449198
ENST00000550795
H0YIE4 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008270 [zinc ion binding]
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 171 aa
18.2 kDa 		No 0
PXN-201
ENSP00000267257
ENST00000267257
P49023 [Direct mapping]
Paxillin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001725 [stress fiber]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0008360 [regulation of cell shape]
GO:0017166 [vinculin binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0031252 [cell leading edge]
GO:0032403 [protein complex binding]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0051435 [BH4 domain binding]
GO:0060396 [growth hormone receptor signaling pathway]
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 605 aa
66.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.