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BRAP

GENERAL INFORMATION

Gene name

 BRAP

Gene description

 BRCA1 associated protein

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA040357
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BRAP (HGNC Symbol)

Synonyms

 BRAP2, IMP, RNF52

Description

 BRCA1 associated protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.12

Chromosome location (bp)

 111642146 - 111685986

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089234 (version 83.38)

Entrez gene

 8315

UniProt

 Q7Z569 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z569

Antibodypedia

 BRAP antibodies

PROTEIN BROWSER
BRAP-001
BRAP-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRAP-001
ENSP00000403524
ENST00000419234
Q7Z569 [Direct mapping]
BRCA1-associated protein
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008139 [nuclear localization sequence binding]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031965 [nuclear membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043130 [ubiquitin binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
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 592 aa
67.3 kDa 		No 0
BRAP-002
ENSP00000330813
ENST00000327551
J3KNN7 [Direct mapping]
BRCA1-associated protein
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0043130 [ubiquitin binding]
Show all
 562 aa
64.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.