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Most cancers displayed weak to moderate cytoplasmic immunoreactivity. Additional nuclear staining was displayed in hepatocellular carcinomas and endometrial cancers. Several non-Hodgkin's lymphomas along with few melanomas and hepatocellular carcinomas were strongly stained.
GENE INFORMATION
Gene name
GMIP (HGNC Symbol)
Synonyms
ARHGAP46
Description
GEM interacting protein (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0034260 [negative regulation of GTPase activity] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0098779 [mitophagy in response to mitochondrial depolarization]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0034260 [negative regulation of GTPase activity] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0098779 [mitophagy in response to mitochondrial depolarization]