Expression of DDX24 in cancer - Summary - The Human Protein Atlas

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DDX24

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DDX24
Gene description	DEAD (Asp-Glu-Ala-Asp) box helicase 24
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (MCF7, NB-4, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA002554
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002554

GENE INFORMATION
Gene name	DDX24
Synonyms
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 24 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.12
Chromosome location (bp)	94048291 - 94081245
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089737 (version 83.38)
Entrez gene	57062
UniProt	Q9GZR7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZR7
Antibodypedia	DDX24 antibodies

PROTEIN BROWSER

DDX24-001	DDX24-003	DDX24-004	DDX24-201	DDX24-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX24-001 ENSP00000481495 ENST00000621632	Q9GZR7 [Direct mapping] ATP-dependent RNA helicase DDX24 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003724 [RNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0016070 [RNA metabolic process] GO:0044822 [poly(A) RNA binding] Show all	859 aa 96.3 kDa	No	0
DDX24-003 ENSP00000440623 ENST00000544005	F5GYL3 [Direct mapping] ATP-dependent RNA helicase DDX24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	609 aa 69 kDa	No	0
DDX24-004 ENSP00000452145 ENST00000555054	G3V529 [Direct mapping] ATP-dependent RNA helicase DDX24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	816 aa 91.5 kDa	No	0
DDX24-201 ENSP00000328690 ENST00000330836	Q9GZR7 [Direct mapping] ATP-dependent RNA helicase DDX24 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003724 [RNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0016070 [RNA metabolic process] GO:0044822 [poly(A) RNA binding] Show all	804 aa 90.3 kDa	No	0
DDX24-202 ENSP00000481317 ENST00000622786	A0A087WXU8 [Direct mapping] ATP-dependent RNA helicase DDX24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	485 aa 55.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.