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ARHGAP4

GENERAL INFORMATION

Gene name

 ARHGAP4

Gene description

 Rho GTPase activating protein 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RPMI-8226)
HPA (normal tissue):Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in bone marrow and lymphoid tissues as well as in immune cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001012 , HPA001083
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable), cervical cancer (favourable), renal cancer (unfavourable) and head and neck cancer (favourable).
Colorectal cancer p<0.001
Cervical cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA001012
HPA001083

GENE INFORMATION

Gene name

 ARHGAP4 (HGNC Symbol)

Synonyms

 C1, KIAA0131, p115, RhoGAP4, SrGAP4

Description

 Rho GTPase activating protein 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153907367 - 153934999

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089820 (version 83.38)

Entrez gene

 393

UniProt

 P98171 (UniProt - Evidence at protein level)

neXtProt

 NX_P98171

Antibodypedia

 ARHGAP4 antibodies

PROTEIN BROWSER
«
ARHGAP4-001
ARHGAP4-003
ARHGAP4-004
ARHGAP4-005
ARHGAP4-009
ARHGAP4-010
ARHGAP4-011
ARHGAP4-015
ARHGAP4-017
ARHGAP4-019
ARHGAP4-020
ARHGAP4-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP4-001
ENSP00000359045
ENST00000370028
P98171 [Direct mapping]
Rho GTPase-activating protein 4
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007399 [nervous system development]
GO:0009967 [positive regulation of signal transduction]
GO:0010764 [negative regulation of fibroblast migration]
GO:0030336 [negative regulation of cell migration]
GO:0030426 [growth cone]
GO:0030517 [negative regulation of axon extension]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 986 aa
109.4 kDa 		No 0
ARHGAP4-003
ENSP00000203786
ENST00000350060
P98171 [Direct mapping]
Rho GTPase-activating protein 4
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0030336 [negative regulation of cell migration]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 946 aa
105 kDa 		No 0
ARHGAP4-004
ENSP00000473936
ENST00000488269
S4R352 [Direct mapping]
Rho GTPase-activating protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 278 aa
31.6 kDa 		No 0
ARHGAP4-005
ENSP00000398019
ENST00000422918
H7C120 [Direct mapping]
Rho GTPase-activating protein 4
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 214 aa
24.1 kDa 		No 0
ARHGAP4-009
ENSP00000412437
ENST00000454164
H7C3K8 [Direct mapping]
Rho GTPase-activating protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 249 aa
26.8 kDa 		No 0
ARHGAP4-010
ENSP00000408656
ENST00000442172
H7C2Z8 [Direct mapping]
Rho GTPase-activating protein 4
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 294 aa
32.5 kDa 		No 0
ARHGAP4-011
ENSP00000359033
ENST00000370016
E7EQN5 [Direct mapping]
Rho GTPase-activating protein 4
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 925 aa
102.6 kDa 		No 0
ARHGAP4-015
ENSP00000473840
ENST00000461052
S4R314 [Direct mapping]
Rho GTPase-activating protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 317 aa
35.9 kDa 		No 0
ARHGAP4-017
ENSP00000398259
ENST00000442262
C9J5M2 [Direct mapping]
Rho GTPase-activating protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 177 aa
20.6 kDa 		No 0
ARHGAP4-019
ENSP00000413782
ENST00000422091
C9JLA8 [Direct mapping]
Rho GTPase-activating protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 174 aa
20.2 kDa 		No 0
ARHGAP4-020
ENSP00000411712
ENST00000418750
H7C3G3 [Direct mapping]
Rho GTPase-activating protein 4
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
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 196 aa
21.5 kDa 		No 0
ARHGAP4-024
ENSP00000377322
ENST00000393721
E9PCM6 [Direct mapping]
Rho GTPase-activating protein 4
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0030336 [negative regulation of cell migration]
GO:0048365 [Rac GTPase binding]
Show all
 768 aa
85.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.