Expression of LTBP4 in cancer - Summary - The Human Protein Atlas

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LTBP4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LTBP4
Gene description	Latent transforming growth factor beta binding protein 4
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	13
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular deposits and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. CAB015194
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB015194

GENE INFORMATION
Gene name	LTBP4 (HGNC Symbol)
Synonyms	FLJ46318, FLJ90018, LTBP-4, LTBP-4L
Description	Latent transforming growth factor beta binding protein 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40592883 - 40629818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090006 (version 83.38)
Entrez gene	8425
UniProt	Q8N2S1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N2S1
Antibodypedia	LTBP4 antibodies

PROTEIN BROWSER

LTBP4-001	LTBP4-002	LTBP4-007	LTBP4-008	LTBP4-009	LTBP4-010	LTBP4-015	LTBP4-017	LTBP4-024	LTBP4-025	LTBP4-027	LTBP4-032	LTBP4-040

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTBP4-001 ENSP00000311905 ENST00000308370	Q8N2S1 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006457 [protein folding] GO:0007275 [multicellular organismal development] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0030162 [regulation of proteolysis] GO:0030198 [extracellular matrix organization] GO:0030252 [growth hormone secretion] GO:0031012 [extracellular matrix] GO:0045595 [regulation of cell differentiation] GO:0050431 [transforming growth factor beta binding] GO:0070062 [extracellular exosome] Show all	1624 aa 173.4 kDa	Yes	0
LTBP4-002 ENSP00000204005 ENST00000204005	A0A0C4DH07 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	1587 aa 169.5 kDa	No	0
LTBP4-007 ENSP00000470824 ENST00000601032	M0QZX0 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	674 aa 72.1 kDa	No	0
LTBP4-008 ENSP00000243562 ENST00000243562	F8WAA0 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	957 aa 102.6 kDa	No	0
LTBP4-009 ENSP00000380031 ENST00000396819	Q8N2S1 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006457 [protein folding] GO:0007275 [multicellular organismal development] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0030162 [regulation of proteolysis] GO:0030198 [extracellular matrix organization] GO:0030252 [growth hormone secretion] GO:0031012 [extracellular matrix] GO:0045595 [regulation of cell differentiation] GO:0050431 [transforming growth factor beta binding] GO:0070062 [extracellular exosome] Show all	1557 aa 165.7 kDa	Yes	0
LTBP4-010 ENSP00000479712 ENST00000612121	A0A087WVV5 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	252 aa 26.4 kDa	No	0
LTBP4-015 ENSP00000469406 ENST00000593463	M0QXV3 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	191 aa 20.3 kDa	No	0
LTBP4-017 ENSP00000469785 ENST00000599724	M0QYE9 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	303 aa 32.6 kDa	No	0
LTBP4-024 ENSP00000479612 ENST00000599225	A0A087WVR1 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	94 aa 10.3 kDa	No	0
LTBP4-025 ENSP00000481081 ENST00000598166	A0A087WXJ2 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	145 aa 15.9 kDa	No	0
LTBP4-027 ENSP00000472995 ENST00000597071	M0R351 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	224 aa 23.3 kDa	No	0
LTBP4-032 ENSP00000478928 ENST00000622457	A0A087WUU1 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	182 aa 19.5 kDa	No	0
LTBP4-040 ENSP00000480888 ENST00000618486	A0A087WXC2 [Direct mapping] Latent-transforming growth factor beta-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	189 aa 19.9 kDa	No	0

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