Cell atlas - CCNK - The Human Protein Atlas

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CCNK

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CCNK
Gene description	Cyclin K
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA000645
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000645	MCF7	Nucleoplasm
	HPA000645	U-251 MG	No staining

GENE INFORMATION
Gene name	CCNK (HGNC Symbol)
Synonyms	CPR4
Description	Cyclin K (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	99481169 - 99535044
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090061 (version 83.38)
Entrez gene	8812
UniProt	O75909 (UniProt - Evidence at protein level)
neXtProt	NX_O75909
Antibodypedia	CCNK antibodies

PROTEIN BROWSER

CCNK-001	CCNK-003	CCNK-006	CCNK-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNK-001 ENSP00000374529 ENST00000389879	O75909 [Direct mapping] Cyclin-K A0A024R6K1 [Target identity:100%; Query identity:100%] Cyclin K, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001701 [in utero embryonic development] GO:0002944 [cyclin K-CDK12 complex] GO:0002945 [cyclin K-CDK13 complex] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0007067 [mitotic nuclear division] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901 [protein kinase binding] GO:0044828 [negative regulation by host of viral genome replication] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051301 [cell division] GO:0071157 [negative regulation of cell cycle arrest] GO:2001165 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues] Show all	580 aa 64.2 kDa	No	0
CCNK-003 ENSP00000452307 ENST00000555049	G3V5E1 [Direct mapping] Cyclin-K Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0019901 [protein kinase binding] Show all	378 aa 43.4 kDa	No	0
CCNK-006 ENSP00000450792 ENST00000557441	G3V2Q3 [Direct mapping] Cyclin-K Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0019901 [protein kinase binding] Show all	227 aa 26.4 kDa	No	0
CCNK-008 ENSP00000450440 ENST00000555842	G3V235 [Direct mapping] Cyclin-K Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0019901 [protein kinase binding] Show all	110 aa 12.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.