Cell atlas - PCBP4 - The Human Protein Atlas

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PCBP4

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PCBP4
Gene description	Poly(rC) binding protein 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA057754
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057754	HeLa	Cytosol
	HPA057754	MCF7	Cytosol
	HPA057754	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PCBP4 (HGNC Symbol)
Synonyms	LIP4, MCG10
Description	Poly(rC) binding protein 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.2
Chromosome location (bp)	51957454 - 51974016
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090097 (version 83.38)
Entrez gene	57060
UniProt	P57723 (UniProt - Evidence at transcript level)
neXtProt	NX_P57723
Antibodypedia	PCBP4 antibodies

PROTEIN BROWSER

PCBP4-001	PCBP4-002	PCBP4-003	PCBP4-007	PCBP4-010	PCBP4-012	PCBP4-013	PCBP4-014	PCBP4-015	PCBP4-016	PCBP4-017	PCBP4-201	PCBP4-202	PCBP4-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCBP4-001 ENSP00000348111 ENST00000355852	P57723 [Direct mapping] Poly(rC)-binding protein 4 A0A024R320 [Target identity:100%; Query identity:100%] Poly(RC) binding protein 4, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	403 aa 41.5 kDa	No	0
PCBP4-002 ENSP00000417196 ENST00000461554	P57723 [Direct mapping] Poly(rC)-binding protein 4 A0A024R320 [Target identity:100%; Query identity:100%] Poly(RC) binding protein 4, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	403 aa 41.5 kDa	No	0
PCBP4-003 ENSP00000417100 ENST00000484633	P57723 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	360 aa 37.1 kDa	No	0
PCBP4-007 ENSP00000418925 ENST00000471622	C9J0A4 [Direct mapping] Poly(rC)-binding protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	323 aa 33.4 kDa	No	0
PCBP4-010 ENSP00000419672 ENST00000461544	C9K0A2 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	46 aa 5 kDa	No	0
PCBP4-012 ENSP00000418997 ENST00000483411	C9IZV9 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	75 aa 8 kDa	No	0
PCBP4-013 ENSP00000418312 ENST00000490063	C9J7A9 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	86 aa 9.2 kDa	No	0
PCBP4-014 ENSP00000419557 ENST00000466412	C9JTY5 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	124 aa 13 kDa	No	0
PCBP4-015 ENSP00000417916 ENST00000497653	C9J5V4 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	107 aa 11.3 kDa	No	0
PCBP4-016 ENSP00000419694 ENST00000468324	C9JZY3 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	168 aa 17.6 kDa	No	0
PCBP4-017 ENSP00000420008 ENST00000489595	C9JSA6 [Direct mapping] Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	92 aa 9.8 kDa	No	0
PCBP4-201 ENSP00000322341 ENST00000322099	P57723 [Direct mapping] Poly(rC)-binding protein 4 A0A024R320 [Target identity:100%; Query identity:100%] Poly(RC) binding protein 4, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	403 aa 41.5 kDa	No	0
PCBP4-202 ENSP00000378461 ENST00000395014	F6TJN8 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	378 aa 38.9 kDa	No	0
PCBP4-203 ENSP00000395030 ENST00000428823	P57723 [Direct mapping] Poly(rC)-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	360 aa 37.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.