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MAEA

GENERAL INFORMATION

Gene name

 MAEA

Gene description

 Macrophage erythroblast attacher

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA058185
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA058185

GENE INFORMATION

Gene name

 MAEA (HGNC Symbol)

Synonyms

 EMP, GID9

Description

 Macrophage erythroblast attacher (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 1289851 - 1340147

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090316 (version 83.38)

Entrez gene

 10296

UniProt

 Q7L5Y9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L5Y9

Antibodypedia

 MAEA antibodies

PROTEIN BROWSER
MAEA-001
MAEA-002
MAEA-003
MAEA-004
MAEA-006
MAEA-007
MAEA-016
MAEA-017
MAEA-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAEA-001
ENSP00000302830
ENST00000303400
Q7L5Y9 [Direct mapping]
Macrophage erythroblast attacher
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005826 [actomyosin contractile ring]
GO:0005856 [cytoskeleton]
GO:0005887 [integral component of plasma membrane]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007346 [regulation of mitotic cell cycle]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0043249 [erythrocyte maturation]
GO:0048821 [erythrocyte development]
GO:0048822 [enucleate erythrocyte development]
GO:0051301 [cell division]
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 396 aa
45.3 kDa 		No 0
MAEA-002
ENSP00000422215
ENST00000505177
E7ESC7 [Direct mapping]
Macrophage erythroblast attacher
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 434 aa
49.4 kDa 		No 0
MAEA-003
ENSP00000264750
ENST00000264750
Q7L5Y9 [Direct mapping]
Macrophage erythroblast attacher
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005826 [actomyosin contractile ring]
GO:0005856 [cytoskeleton]
GO:0005887 [integral component of plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016363 [nuclear matrix]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0043249 [erythrocyte maturation]
GO:0051301 [cell division]
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 355 aa
40.4 kDa 		No 0
MAEA-004
ENSP00000427512
ENST00000514708
D6RIB6 [Direct mapping]
Macrophage erythroblast attacher
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
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 328 aa
36.2 kDa 		No 0
MAEA-006
ENSP00000426807
ENST00000510794
B4DVN3 [Direct mapping]
Macrophage erythroblast attacher; cDNA FLJ54556, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 395 aa
45.1 kDa 		No 0
MAEA-007
ENSP00000424436
ENST00000505839
B4DQT1 [Direct mapping]
Macrophage erythroblast attacher; cDNA FLJ53639, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 348 aa
39.8 kDa 		No 0
MAEA-016
ENSP00000427460
ENST00000512842
D6RID6 [Direct mapping]
Macrophage erythroblast attacher
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
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 115 aa
12.9 kDa 		No 0
MAEA-017
ENSP00000421644
ENST00000503653
D6REW7 [Direct mapping]
Macrophage erythroblast attacher
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
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 274 aa
30.4 kDa 		No 0
MAEA-018
ENSP00000426903
ENST00000502558
D6RE80 [Direct mapping]
Macrophage erythroblast attacher
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 183 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.