Expression of STRN4 in cancer - Summary

GENERAL INFORMATION
Gene name	STRN4
Gene description	Striatin, calmodulin binding protein 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and some membranous expression, most abundant in reproductive organs.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA043527 , HPA056706
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (unfavourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043527	HPA056706

GENE INFORMATION
Gene name	STRN4 (HGNC Symbol)
Synonyms	ZIN, zinedin
Description	Striatin, calmodulin binding protein 4 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	46719507 - 46746994
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090372 (version 83.38)
Entrez gene	29888
UniProt	Q9NRL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRL3
Antibodypedia	STRN4 antibodies

PROTEIN BROWSER

STRN4-001	STRN4-002	STRN4-004	STRN4-008	STRN4-009	STRN4-012	STRN4-013	STRN4-021	STRN4-023

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STRN4-001 ENSP00000263280 ENST00000263280	Q9NRL3 [Direct mapping] Striatin-4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0043197 [dendritic spine] GO:0051721 [protein phosphatase 2A binding] GO:0070016 [armadillo repeat domain binding] Show all	753 aa 80.6 kDa	No	0
STRN4-002 ENSP00000375777 ENST00000391910	Q9NRL3 [Direct mapping] Striatin-4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0019904 [protein domain specific binding] GO:0032403 [protein complex binding] GO:0043197 [dendritic spine] GO:0043234 [protein complex] GO:0051721 [protein phosphatase 2A binding] GO:0070016 [armadillo repeat domain binding] Show all	760 aa 81.3 kDa	No	0
STRN4-004 ENSP00000440901 ENST00000539396	F5GYK2 [Direct mapping] Striatin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	634 aa 68.6 kDa	No	0
STRN4-008 ENSP00000471354 ENST00000593979	M0R0P4 [Direct mapping] Striatin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.3 kDa	No	0
STRN4-009 ENSP00000469279 ENST00000596012	M0QXN2 [Direct mapping] Striatin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8.4 kDa	No	0
STRN4-012 ENSP00000470040 ENST00000597063	M0QYS2 [Direct mapping] Striatin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.7 kDa	No	0
STRN4-013 ENSP00000472429 ENST00000597021	M0R2A7 [Direct mapping] Striatin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.6 kDa	No	0
STRN4-021 ENSP00000470634 ENST00000594287	M0QZM0 [Direct mapping] Striatin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	317 aa 34.2 kDa	No	1
STRN4-023 ENSP00000472938 ENST00000600615	M0R317 [Direct mapping] Striatin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	198 aa 20.9 kDa	No	0