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IRAK3

GENERAL INFORMATION

Gene name

 IRAK3

Gene description

 Interleukin-1 receptor-associated kinase 3

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL, HL-60, THP-1, U-937)
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic positivity in several different cell types, most abundant in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA043097
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043097

GENE INFORMATION

Gene name

 IRAK3 (HGNC Symbol)

Synonyms

 IRAK-M

Description

 Interleukin-1 receptor-associated kinase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 q14.3

Chromosome location (bp)

 66188879 - 66254622

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090376 (version 83.38)

Entrez gene

 11213

UniProt

 Q9Y616 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y616

Antibodypedia

 IRAK3 antibodies

PROTEIN BROWSER
IRAK3-001
IRAK3-002
IRAK3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRAK3-001
ENSP00000261233
ENST00000261233
Q9Y616 [Direct mapping]
Interleukin-1 receptor-associated kinase 3
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   SignalP predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0009615 [response to virus]
GO:0010933 [positive regulation of macrophage tolerance induction]
GO:0010936 [negative regulation of macrophage cytokine production]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0034122 [negative regulation of toll-like receptor signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043242 [negative regulation of protein complex disassembly]
GO:0043244 [regulation of protein complex disassembly]
GO:0043330 [response to exogenous dsRNA]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045824 [negative regulation of innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
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 596 aa
67.8 kDa 		No 0
IRAK3-002
ENSP00000441321
ENST00000545837
F5GYN6 [Direct mapping]
Interleukin-1 receptor-associated kinase 3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0035556 [intracellular signal transduction]
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 93 aa
10 kDa 		Yes 0
IRAK3-003
ENSP00000409852
ENST00000457197
Q9Y616 [Direct mapping]
Interleukin-1 receptor-associated kinase 3
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0009615 [response to virus]
GO:0010933 [positive regulation of macrophage tolerance induction]
GO:0010936 [negative regulation of macrophage cytokine production]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0034122 [negative regulation of toll-like receptor signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043242 [negative regulation of protein complex disassembly]
GO:0043244 [regulation of protein complex disassembly]
GO:0043330 [response to exogenous dsRNA]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045824 [negative regulation of innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
Show all
 535 aa
60.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.