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SI

GENERAL INFORMATION

Gene name

 SI

Gene description

 Sucrase-isomaltase (alpha-glucosidase)

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (stomach cancer)
HPA (cell line):Cell line enhanced (BEWO, CACO-2, RPMI-8226, SH-SY5Y)
HPA (normal tissue):Group enriched (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Luminal membranous expression in duodenum and small intestine.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA011897
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011897

GENE INFORMATION

Gene name

 SI

Synonyms

Description

 Sucrase-isomaltase (alpha-glucosidase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010]

Chromosome

 3

Cytoband

 q26.1

Chromosome location (bp)

 164978898 - 165078495

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090402 (version 83.38)

Entrez gene

 6476

UniProt

 P14410 (UniProt - Evidence at protein level)

neXtProt

 NX_P14410

Antibodypedia

 SI antibodies

PROTEIN BROWSER
SI-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SI-001
ENSP00000264382
ENST00000264382
P14410 [Direct mapping]
Sucrase-isomaltase, intestinal Sucrase Isomaltase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004558 [alpha-1,4-glucosidase activity]
GO:0004574 [oligo-1,6-glucosidase activity]
GO:0004575 [sucrose alpha-glucosidase activity]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005975 [carbohydrate metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0030246 [carbohydrate binding]
GO:0044245 [polysaccharide digestion]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 1827 aa
209.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.