Cell atlas - DNAJB11 - The Human Protein Atlas

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DNAJB11

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	DNAJB11
Gene description	DnaJ (Hsp40) homolog, subfamily B, member 11
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Mouse	Localized to the Endoplasmic reticulum in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA010814
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA010814	A-431	Endoplasmic reticulum
	HPA010814	U-2 OS	Endoplasmic reticulum
	HPA010814	U-251 MG	Endoplasmic reticulum

MOUSE CELLS

Main location

Endoplasmic reticulum

Mouse gene

ENSMUSG00000004460 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA010814	NIH 3T3	Endoplasmic reticulum

GENE INFORMATION
Gene name	DNAJB11 (HGNC Symbol)
Synonyms	EDJ, ERdj3, HEDJ
Description	DnaJ (Hsp40) homolog, subfamily B, member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]
Chromosome	3
Cytoband	q27.3
Chromosome location (bp)	186567403 - 186597203
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090520 (version 83.38)
Entrez gene	51726
UniProt	Q9UBS4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBS4
Antibodypedia	DNAJB11 antibodies

PROTEIN BROWSER

DNAJB11-001	DNAJB11-005	DNAJB11-201	DNAJB11-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJB11-001 ENSP00000414398 ENST00000439351	Q9UBS4 [Direct mapping] DnaJ homolog subfamily B member 11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032781 [positive regulation of ATPase activity] GO:0034663 [endoplasmic reticulum chaperone complex] GO:0036498 [IRE1-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0051082 [unfolded protein binding] Show all	358 aa 40.5 kDa	Yes	0
DNAJB11-005 ENSP00000408410 ENST00000418776	H7C2Y5 [Direct mapping] DnaJ homolog subfamily B member 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	168 aa 19.2 kDa	No	0
DNAJB11-201 ENSP00000265028 ENST00000265028	Q9UBS4 [Direct mapping] DnaJ homolog subfamily B member 11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032781 [positive regulation of ATPase activity] GO:0036498 [IRE1-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0051082 [unfolded protein binding] Show all	358 aa 40.5 kDa	Yes	0
DNAJB11-202 ENSP00000440189 ENST00000538831	F5GXK8 [Direct mapping] DnaJ homolog subfamily B member 11 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	75 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.