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Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Cancer tissues displayed weak to moderate cytoplasmic positivity with additional membranous staining in several cases. Extracellular material was distinctly stained. Several embryonal carcinomas of testis were strongly stained.
GENE INFORMATION
Gene name
CHRD
Synonyms
Description
Chordin (HGNC Symbol)
Entrez gene summary
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]