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GOLGA3

GENERAL INFORMATION

Gene name

 GOLGA3

Gene description

 Golgin A3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039809 , HPA040044
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039809
HPA040044

GENE INFORMATION

Gene name

 GOLGA3 (HGNC Symbol)

Synonyms

 GCP170, golgin-160, MEA-2

Description

 Golgin A3 (HGNC Symbol)

Entrez gene summary

 The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 132768909 - 132828858

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090615 (version 83.38)

Entrez gene

 2802

UniProt

 Q08378 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08378

Antibodypedia

 GOLGA3 antibodies

PROTEIN BROWSER
GOLGA3-001
GOLGA3-003
GOLGA3-201
GOLGA3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GOLGA3-001
ENSP00000410378
ENST00000450791
Q08378 [Direct mapping]
Golgin subfamily A member 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0017119 [Golgi transport complex]
GO:0032580 [Golgi cisterna membrane]
GO:0090498 [extrinsic component of Golgi membrane]
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 1498 aa
167.4 kDa 		No 0
GOLGA3-003
ENSP00000409303
ENST00000456883
Q08378 [Direct mapping]
Golgin subfamily A member 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0017119 [Golgi transport complex]
GO:0032580 [Golgi cisterna membrane]
GO:0090498 [extrinsic component of Golgi membrane]
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 1390 aa
155.7 kDa 		No 0
GOLGA3-201
ENSP00000204726
ENST00000204726
Q08378 [Direct mapping]
Golgin subfamily A member 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0017119 [Golgi transport complex]
GO:0032580 [Golgi cisterna membrane]
GO:0090498 [extrinsic component of Golgi membrane]
Show all
 1498 aa
167.4 kDa 		No 0
GOLGA3-202
ENSP00000442603
ENST00000545875
Q08378 [Direct mapping]
Golgin subfamily A member 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0017119 [Golgi transport complex]
GO:0032580 [Golgi cisterna membrane]
GO:0090498 [extrinsic component of Golgi membrane]
Show all
 1134 aa
126.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.