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CD209

GENERAL INFORMATION

Gene name

 CD209

Gene description

 CD209 molecule

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (THP-1)
HPA (normal tissue):Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in subsets of monocyte-derived cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
CAB032436 , CAB033831
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB032436
CAB033831

GENE INFORMATION

Gene name

 CD209 (HGNC Symbol)

Synonyms

 CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1

Description

 CD209 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 7739994 - 7747564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090659 (version 83.38)

Entrez gene

 30835

UniProt

 Q9NNX6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NNX6

Antibodypedia

 CD209 antibodies

PROTEIN BROWSER
«
CD209-001
CD209-002
CD209-003
CD209-004
CD209-005
CD209-006
CD209-007
CD209-008
CD209-009
CD209-012
CD209-014
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD209-001
ENSP00000315477
ENST00000315599
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 404 aa
45.8 kDa 		No 1
CD209-002
ENSP00000346373
ENST00000354397
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 398 aa
45 kDa 		No 1
CD209-003
ENSP00000468827
ENST00000601951
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 380 aa
43.1 kDa 		No 0
CD209-004
ENSP00000471348
ENST00000593821
M0R0P0 [Direct mapping]
CD209 antigen; CD209 antigen, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 268 aa
30.5 kDa 		No 0
CD209-005
ENSP00000315407
ENST00000315591
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 380 aa
43.3 kDa 		No 0
CD209-006
ENSP00000471137
ENST00000602261
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 312 aa
35.2 kDa 		No 1
CD209-007
ENSP00000470530
ENST00000593660
M0QZG5 [Direct mapping]
CD209 antigen; CD209 antigen, isoform CRA_j
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 334 aa
37.9 kDa 		No 0
CD209-008
ENSP00000470658
ENST00000601256
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 297 aa
33.9 kDa 		No 0
CD209-009
ENSP00000377728
ENST00000394173
X6RB12 [Direct mapping]
CD209 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 243 aa
27.4 kDa 		No 1
CD209-012
ENSP00000377716
ENST00000394161
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 168 aa
18.6 kDa 		No 1
CD209-014
ENSP00000204801
ENST00000204801
Q9NNX6 [Direct mapping]
CD209 antigen
Show all
CD markers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009986 [cell surface]
GO:0009988 [cell-cell recognition]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030246 [carbohydrate binding]
GO:0035556 [intracellular signal transduction]
GO:0042129 [regulation of T cell proliferation]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
Show all
 360 aa
41 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.