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DLL3

GENERAL INFORMATION

Gene name

 DLL3

Gene description

 Delta-like 3 (Drosophila)

Protein class

 Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, melanoma, testis cancer)
HPA (cell line):Group enriched (SCLC-21H, SH-SY5Y, SK-MEL-30)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, melanoma, testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DLL3 (HGNC Symbol)

Synonyms

 SCDO1

Description

 Delta-like 3 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39498895 - 39508481

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090932 (version 83.38)

Entrez gene

 10683

UniProt

 Q9NYJ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYJ7

Antibodypedia

 DLL3 antibodies

PROTEIN BROWSER
DLL3-001
DLL3-002
DLL3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLL3-001
ENSP00000348810
ENST00000356433
Q9NYJ7 [Direct mapping]
Delta-like protein 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development]
GO:0005112 [Notch binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007219 [Notch signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
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 587 aa
61.2 kDa 		Yes 1
DLL3-002
ENSP00000205143
ENST00000205143
Q9NYJ7 [Direct mapping]
Delta-like protein 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001756 [somitogenesis]
GO:0005112 [Notch binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007219 [Notch signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007386 [compartment pattern specification]
GO:0009888 [tissue development]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0048339 [paraxial mesoderm development]
GO:0050768 [negative regulation of neurogenesis]
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 618 aa
64.6 kDa 		Yes 1
DLL3-005
ENSP00000471688
ENST00000596614
M0R177 [Direct mapping]
Delta-like protein 3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007219 [Notch signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
Show all
 220 aa
23.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.