Expression of OSBPL8 in cancer - Summary - The Human Protein Atlas

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OSBPL8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OSBPL8
Gene description	Oxysterol binding protein-like 8
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in some tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA001309
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001309

GENE INFORMATION
Gene name	OSBPL8 (HGNC Symbol)
Synonyms	MST120, MSTP120, ORP8, OSBP10
Description	Oxysterol binding protein-like 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q21.2
Chromosome location (bp)	76351797 - 76559809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091039 (version 83.38)
Entrez gene	114882
UniProt	Q9BZF1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZF1
Antibodypedia	OSBPL8 antibodies

PROTEIN BROWSER

OSBPL8-001	OSBPL8-002	OSBPL8-003	OSBPL8-004	OSBPL8-006	OSBPL8-007	OSBPL8-008	OSBPL8-009	OSBPL8-010	OSBPL8-011	OSBPL8-013	OSBPL8-014	OSBPL8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSBPL8-001 ENSP00000261183 ENST00000261183	Q9BZF1 [Direct mapping] Oxysterol-binding protein-related protein 8 A0A024RBB8 [Target identity:100%; Query identity:100%] Oxysterol-binding protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005515 [protein binding] GO:0005548 [phospholipid transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030336 [negative regulation of cell migration] GO:0031965 [nuclear membrane] GO:0032148 [activation of protein kinase B activity] GO:0032541 [cortical endoplasmic reticulum] GO:0045444 [fat cell differentiation] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0090204 [protein localization to nuclear pore] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	889 aa 101.2 kDa	No	1
OSBPL8-002 ENSP00000376939 ENST00000393249	Q9BZF1 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0032148 [activation of protein kinase B activity] GO:0032541 [cortical endoplasmic reticulum] GO:0045444 [fat cell differentiation] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	847 aa 97 kDa	No	1
OSBPL8-003 ENSP00000450238 ENST00000547540	F8VQX7 [Direct mapping] Oxysterol-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006869 [lipid transport] Show all	721 aa 81.7 kDa	No	0
OSBPL8-004 ENSP00000376940 ENST00000393250	Q9BZF1 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0032148 [activation of protein kinase B activity] GO:0032541 [cortical endoplasmic reticulum] GO:0045444 [fat cell differentiation] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	847 aa 97 kDa	No	1
OSBPL8-006 ENSP00000447893 ENST00000546946	F8VUA7 [Direct mapping] Oxysterol-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006869 [lipid transport] Show all	695 aa 79.2 kDa	No	0
OSBPL8-007 ENSP00000449618 ENST00000553139	F8VVE7 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.4 kDa	No	0
OSBPL8-008 ENSP00000447483 ENST00000550628	F8W1F1 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 2.9 kDa	No	0
OSBPL8-009 ENSP00000449919 ENST00000549570	F8VVD3 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.4 kDa	No	0
OSBPL8-010 ENSP00000447744 ENST00000551927	F8VZB8 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.1 kDa	No	0
OSBPL8-011 ENSP00000447235 ENST00000547544	F8W060 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 5.6 kDa	No	0
OSBPL8-013 ENSP00000448394 ENST00000549646	F8VS33 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.6 kDa	No	0
OSBPL8-014 ENSP00000446886 ENST00000548341	F8VZ43 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.4 kDa	No	0
OSBPL8-201 ENSP00000478240 ENST00000611266	Q9BZF1 [Direct mapping] Oxysterol-binding protein-related protein 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0032148 [activation of protein kinase B activity] GO:0032541 [cortical endoplasmic reticulum] GO:0045444 [fat cell differentiation] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	847 aa 97 kDa	No	1

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