Expression of PUS7 in cancer - Summary - The Human Protein Atlas

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PUS7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PUS7
Gene description	Pseudouridylate synthase 7 (putative)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA024116
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), melanoma (unfavourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Melanoma p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024116

GENE INFORMATION
Gene name	PUS7 (HGNC Symbol)
Synonyms	FLJ20485
Description	Pseudouridylate synthase 7 (putative) (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q22.3
Chromosome location (bp)	105439661 - 105522267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091127 (version 83.38)
Entrez gene	54517
UniProt	Q96PZ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PZ0
Antibodypedia	PUS7 antibodies

PROTEIN BROWSER

PUS7-001	PUS7-002	PUS7-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PUS7-001 ENSP00000417402 ENST00000469408	Q96PZ0 [Direct mapping] Pseudouridylate synthase 7 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0044822 [poly(A) RNA binding] Show all	661 aa 75 kDa	No	0
PUS7-002 ENSP00000348722 ENST00000356362	Q96PZ0 [Direct mapping] Pseudouridylate synthase 7 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0044822 [poly(A) RNA binding] Show all	661 aa 75 kDa	No	0
PUS7-006 ENSP00000417718 ENST00000482157	H0Y863 [Direct mapping] Pseudouridylate synthase 7 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	132 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.