Expression of NRCAM in cancer - Summary

GENERAL INFORMATION
Gene name	NRCAM
Gene description	Neuronal cell adhesion molecule
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (AF22, EFO-21, HMC-1, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High expression in processes in CNS, cytoplasmic expression an adrenal gland as well.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA012606
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA012606

GENE INFORMATION
Gene name	NRCAM (HGNC Symbol)
Synonyms	Bravo, KIAA0343
Description	Neuronal cell adhesion molecule (HGNC Symbol)
Entrez gene summary	Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	108147623 - 108456717
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091129 (version 83.38)
Entrez gene	4897
UniProt	Q92823 (UniProt - Evidence at protein level)
neXtProt	NX_Q92823
Antibodypedia	NRCAM antibodies

PROTEIN BROWSER

NRCAM-001	NRCAM-003	NRCAM-005	NRCAM-006	NRCAM-011	NRCAM-015	NRCAM-016	NRCAM-017	NRCAM-018	NRCAM-201	NRCAM-202	NRCAM-203	NRCAM-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRCAM-001 ENSP00000368310 ENST00000379024	Q92823 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001764 [neuron migration] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007416 [synapse assembly] GO:0007417 [central nervous system development] GO:0009897 [external side of plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030506 [ankyrin binding] GO:0030516 [regulation of axon extension] GO:0043005 [neuron projection] GO:0043194 [axon initial segment] GO:0045162 [clustering of voltage-gated sodium channels] GO:0045666 [positive regulation of neuron differentiation] Show all	1192 aa 131.7 kDa	Yes	1
NRCAM-003 ENSP00000325269 ENST00000351718	Q92823 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001764 [neuron migration] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007416 [synapse assembly] GO:0007417 [central nervous system development] GO:0009897 [external side of plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030506 [ankyrin binding] GO:0030516 [regulation of axon extension] GO:0043005 [neuron projection] GO:0043194 [axon initial segment] GO:0045162 [clustering of voltage-gated sodium channels] GO:0045666 [positive regulation of neuron differentiation] Show all	1183 aa 131 kDa	Yes	1
NRCAM-005 ENSP00000390421 ENST00000417701	C9JH43 [Direct mapping] Neuronal cell adhesion molecule Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	431 aa 48 kDa	Yes	0
NRCAM-006 ENSP00000401244 ENST00000425651	Q92823 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001764 [neuron migration] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007416 [synapse assembly] GO:0007417 [central nervous system development] GO:0009897 [external side of plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030506 [ankyrin binding] GO:0030516 [regulation of axon extension] GO:0043005 [neuron projection] GO:0043194 [axon initial segment] GO:0045162 [clustering of voltage-gated sodium channels] GO:0045666 [positive regulation of neuron differentiation] Show all	1304 aa 143.9 kDa	Yes	1
NRCAM-011 ENSP00000398174 ENST00000445634	H7C132 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	190 aa 20.6 kDa	No	1
NRCAM-015 ENSP00000397544 ENST00000419936	C9J8B6 [Direct mapping] Neuronal cell adhesion molecule Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	106 aa 11.8 kDa	Yes	0
NRCAM-016 ENSP00000408203 ENST00000456431	C9J8B6 [Direct mapping] Neuronal cell adhesion molecule Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	106 aa 11.8 kDa	Yes	0
NRCAM-017 ENSP00000390868 ENST00000442580	C9JF43 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	118 aa 13.3 kDa	Yes	0
NRCAM-018 ENSP00000393663 ENST00000418239	C9JUR7 [Direct mapping] Neuronal cell adhesion molecule Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 7 kDa	Yes	0
NRCAM-201 ENSP00000368308 ENST00000379022	F8W775 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1299 aa 143.3 kDa	Yes	1
NRCAM-202 ENSP00000368314 ENST00000379028	Q92823 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001764 [neuron migration] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007416 [synapse assembly] GO:0007417 [central nervous system development] GO:0008104 [protein localization] GO:0009897 [external side of plasma membrane] GO:0010975 [regulation of neuron projection development] GO:0016337 [single organismal cell-cell adhesion] GO:0019227 [neuronal action potential propagation] GO:0030424 [axon] GO:0030506 [ankyrin binding] GO:0030516 [regulation of axon extension] GO:0031290 [retinal ganglion cell axon guidance] GO:0034113 [heterotypic cell-cell adhesion] GO:0043005 [neuron projection] GO:0043194 [axon initial segment] GO:0045162 [clustering of voltage-gated sodium channels] GO:0045202 [synapse] GO:0045666 [positive regulation of neuron differentiation] GO:0086080 [protein binding involved in heterotypic cell-cell adhesion] Show all	1304 aa 143.9 kDa	Yes	1
NRCAM-203 ENSP00000407858 ENST00000413765	C9JYY6 [Direct mapping] Neuronal cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1211 aa 133.8 kDa	Yes	1
NRCAM-204 ENSP00000484840 ENST00000613830	A0A087X2B3 [Direct mapping] Neuronal cell adhesion molecule Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	771 aa 85.3 kDa	Yes	0