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SLC26A4

GENERAL INFORMATION

Gene name

 SLC26A4

Gene description

 Solute carrier family 26 (anion exchanger), member 4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (thyroid gland)
GTEx:Tissue enriched (thyroid gland)
FANTOM5:Tissue enriched (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in thyroid gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA042860
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)

GENE INFORMATION

Gene name

 SLC26A4 (HGNC Symbol)

Synonyms

 DFNB4, PDS

Description

 Solute carrier family 26 (anion exchanger), member 4 (HGNC Symbol)

Entrez gene summary

 Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.3

Chromosome location (bp)

 107660635 - 107717809

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091137 (version 83.38)

Entrez gene

 5172

UniProt

 O43511 (UniProt - Evidence at protein level)

neXtProt

 NX_O43511

Antibodypedia

 SLC26A4 antibodies

PROTEIN BROWSER
SLC26A4-001
SLC26A4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC26A4-001
ENSP00000265715
ENST00000265715
O43511 [Direct mapping]
Pendrin
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006885 [regulation of pH]
GO:0007605 [sensory perception of sound]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015111 [iodide transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015698 [inorganic anion transport]
GO:0015701 [bicarbonate transport]
GO:0015705 [iodide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0031526 [brush border membrane]
GO:0032880 [regulation of protein localization]
GO:0042391 [regulation of membrane potential]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
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 780 aa
85.7 kDa 		No >9
SLC26A4-002
ENSP00000394760
ENST00000440056
C9JQG1 [Direct mapping]
Pendrin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:1902358 [sulfate transmembrane transport]
Show all
 131 aa
14.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.