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ITGA6

GENERAL INFORMATION

Gene name

 ITGA6

Gene description

 Integrin, alpha 6

Protein class

 Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ, HaCaT)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in solid tissues, most abundant in basal membranes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA012696 , HPA027582 , CAB009009
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012696
HPA027582
CAB009009

GENE INFORMATION

Gene name

 ITGA6 (HGNC Symbol)

Synonyms

 CD49f

Description

 Integrin, alpha 6 (HGNC Symbol)

Entrez gene summary

 The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 172427354 - 172506282

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091409 (version 83.38)

Entrez gene

 3655

UniProt

 P23229 (UniProt - Evidence at protein level)

neXtProt

 NX_P23229

Antibodypedia

 ITGA6 antibodies

PROTEIN BROWSER
ITGA6-001
ITGA6-002
ITGA6-003
ITGA6-004
ITGA6-006
ITGA6-010
ITGA6-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITGA6-001
ENSP00000264107
ENST00000264107
P23229 [Direct mapping]
Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain Processed integrin alpha-6
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007044 [cell-substrate junction assembly]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010668 [ectodermal cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0031589 [cell-substrate adhesion]
GO:0034329 [cell junction assembly]
GO:0035878 [nail development]
GO:0042327 [positive regulation of phosphorylation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0043588 [skin development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048565 [digestive tract development]
GO:0050900 [leukocyte migration]
GO:0072001 [renal system development]
GO:0097186 [amelogenesis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1073 aa
119.5 kDa 		Yes 1
ITGA6-002
ENSP00000413470
ENST00000412899
C9JXX7 [Direct mapping]
Integrin alpha-6
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0008305 [integrin complex]
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 231 aa
25.5 kDa 		No 0
ITGA6-003
ENSP00000386614
ENST00000409532
P23229 [Direct mapping]
Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain Processed integrin alpha-6
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007044 [cell-substrate junction assembly]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010668 [ectodermal cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0031589 [cell-substrate adhesion]
GO:0034329 [cell junction assembly]
GO:0035878 [nail development]
GO:0042327 [positive regulation of phosphorylation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0043588 [skin development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048565 [digestive tract development]
GO:0050900 [leukocyte migration]
GO:0072001 [renal system development]
GO:0097186 [amelogenesis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 954 aa
106.6 kDa 		No 1
ITGA6-004
ENSP00000386896
ENST00000409080
P23229 [Direct mapping]
Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain Processed integrin alpha-6
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007044 [cell-substrate junction assembly]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008305 [integrin complex]
GO:0009897 [external side of plasma membrane]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010668 [ectodermal cell differentiation]
GO:0016323 [basolateral plasma membrane]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030056 [hemidesmosome]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0031589 [cell-substrate adhesion]
GO:0031668 [cellular response to extracellular stimulus]
GO:0033627 [cell adhesion mediated by integrin]
GO:0034329 [cell junction assembly]
GO:0035878 [nail development]
GO:0042327 [positive regulation of phosphorylation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0043588 [skin development]
GO:0045178 [basal part of cell]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046847 [filopodium assembly]
GO:0046872 [metal ion binding]
GO:0048565 [digestive tract development]
GO:0050873 [brown fat cell differentiation]
GO:0050900 [leukocyte migration]
GO:0072001 [renal system development]
GO:0097186 [amelogenesis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1091 aa
122.1 kDa 		Yes 1
ITGA6-006
ENSP00000388435
ENST00000416789
H7BZ97 [Direct mapping]
Integrin alpha-6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 258 aa
29.7 kDa 		No 1
ITGA6-010
ENSP00000406694
ENST00000442250
P23229 [Direct mapping]
Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain Processed integrin alpha-6
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007044 [cell-substrate junction assembly]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010668 [ectodermal cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0031589 [cell-substrate adhesion]
GO:0034329 [cell junction assembly]
GO:0035878 [nail development]
GO:0042327 [positive regulation of phosphorylation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0043588 [skin development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048565 [digestive tract development]
GO:0050900 [leukocyte migration]
GO:0072001 [renal system development]
GO:0097186 [amelogenesis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1130 aa
126.6 kDa 		Yes 1
ITGA6-011
ENSP00000394169
ENST00000458358
P23229 [Direct mapping]
Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain Processed integrin alpha-6
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007044 [cell-substrate junction assembly]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010668 [ectodermal cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0031589 [cell-substrate adhesion]
GO:0034329 [cell junction assembly]
GO:0035878 [nail development]
GO:0042327 [positive regulation of phosphorylation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0043588 [skin development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048565 [digestive tract development]
GO:0050900 [leukocyte migration]
GO:0072001 [renal system development]
GO:0097186 [amelogenesis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1086 aa
121.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.