Expression of CPA1 in cancer - Summary - The Human Protein Atlas

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CPA1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CPA1
Gene description	Carboxypeptidase A1 (pancreatic)
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Cell line enhanced (AN3-CA, SCLC-21H)
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in exocrine glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA021836 , HPA052215 , CAB025197
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021836	HPA052215	CAB025197

GENE INFORMATION
Gene name	CPA1 (HGNC Symbol)
Synonyms	CPA
Description	Carboxypeptidase A1 (pancreatic) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]
Chromosome	7
Cytoband	q32.2
Chromosome location (bp)	130380339 - 130388114
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091704 (version 83.38)
Entrez gene	1357
UniProt	P15085 (UniProt - Evidence at protein level)
neXtProt	NX_P15085
Antibodypedia	CPA1 antibodies

PROTEIN BROWSER

CPA1-001	CPA1-003	CPA1-005	CPA1-007	CPA1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPA1-001 ENSP00000011292 ENST00000011292	P15085 [Direct mapping] Carboxypeptidase A1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008238 [exopeptidase activity] GO:0008270 [zinc ion binding] Show all	419 aa 47.1 kDa	Yes	0
CPA1-003 ENSP00000419497 ENST00000484324	C9JUF9 [Direct mapping] Carboxypeptidase A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	331 aa 37.4 kDa	No	0
CPA1-005 ENSP00000420218 ENST00000481342	C9JQ63 [Direct mapping] Carboxypeptidase A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	103 aa 11.9 kDa	No	0
CPA1-007 ENSP00000419408 ENST00000476062	C9JUZ4 [Direct mapping] Carboxypeptidase A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	269 aa 30.2 kDa	No	0
CPA1-010 ENSP00000475021 ENST00000604896	S4R433 [Direct mapping] Carboxypeptidase A1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	191 aa 20.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.