Fields »
ABOUT
HELP
BLOG
TRPM7

GENERAL INFORMATION

Gene name

 TRPM7

Gene description

 Transient receptor potential cation channel, subfamily M, member 7

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA035523
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035523

GENE INFORMATION

Gene name

 TRPM7 (HGNC Symbol)

Synonyms

 CHAK1, LTRPC7, TRP-PLIK

Description

 Transient receptor potential cation channel, subfamily M, member 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 50552473 - 50686815

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092439 (version 83.38)

Entrez gene

 54822

UniProt

 Q96QT4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QT4

Antibodypedia

 TRPM7 antibodies

PROTEIN BROWSER
TRPM7-001
TRPM7-002
TRPM7-004
TRPM7-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPM7-001
ENSP00000320239
ENST00000313478
Q96QT4 [Direct mapping]
Transient receptor potential cation channel subfamily M member 7
A0A024R5V1 [Target identity:100%; Query identity:100%]
Transient receptor potential cation channel, subfamily M, member 7, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0010961 [cellular magnesium ion homeostasis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016340 [calcium-dependent cell-matrix adhesion]
GO:0017022 [myosin binding]
GO:0031032 [actomyosin structure organization]
GO:0034220 [ion transmembrane transport]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070266 [necroptotic process]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1865 aa
212.7 kDa 		No 6
TRPM7-002
ENSP00000453277
ENST00000560955
H0YLN8 [Direct mapping]
Transient receptor potential cation channel subfamily M member 7; Transient receptor potential cation channel, subfamily M, member 7, isoform CRA_c
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005216 [ion channel activity]
GO:0005524 [ATP binding]
GO:0005623 [cell]
GO:0006468 [protein phosphorylation]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0010961 [cellular magnesium ion homeostasis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
Show all
 1864 aa
212.6 kDa 		No 6
TRPM7-004
ENSP00000452873
ENST00000560638
A0A0C4DGL2 [Direct mapping]
Transient receptor potential cation channel subfamily M member 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005623 [cell]
GO:0006468 [protein phosphorylation]
GO:0006812 [cation transport]
GO:0010961 [cellular magnesium ion homeostasis]
GO:0016021 [integral component of membrane]
Show all
 535 aa
62.7 kDa 		No 5
TRPM7-010
ENSP00000454066
ENST00000561267
H0YNM0 [Direct mapping]
Transient receptor potential cation channel subfamily M member 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005623 [cell]
GO:0006468 [protein phosphorylation]
GO:0006812 [cation transport]
GO:0010961 [cellular magnesium ion homeostasis]
GO:0016021 [integral component of membrane]
Show all
 234 aa
26.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.