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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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EZR
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    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

EZR

Gene description

Ezrin

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA021616 , CAB004035 , CAB047324
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY

HPA021616
CAB004035
CAB047324

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells showed moderate to strong cytoplasmic and occasional membranous immunoreactivity. Hepatocellular carcinomas were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed moderate to strong cytoplasmic and membranous immunoreactivity. Strongest staining was observed in lymphomas and breast cancers.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed moderate to strong cytoplasmic immunoreactivity with additional membranous staining in several cases. Several cases of glioma were negative.

GENE INFORMATION

Gene name

EZR (HGNC Symbol)

Synonyms

VIL2

Description

Ezrin (HGNC Symbol)

Entrez gene summary

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q25.3

Chromosome location (bp)

158765741 - 158819412

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000092820 (version 83.38)

Entrez gene

7430

UniProt

P15311 (UniProt - Evidence at protein level)

neXtProt

NX_P15311

Antibodypedia

EZR antibodies

PROTEIN BROWSER

EZR-001
EZR-002
EZR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EZR-001
ENSP00000356042
ENST00000367075
P15311 [Direct mapping]
Ezrin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001726 [ruffle]
GO:0001772 [immunological synapse]
GO:0001931 [uropod]
GO:0001951 [intestinal D-glucose absorption]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0022614 [membrane to membrane docking]
GO:0030033 [microvillus assembly]
GO:0030175 [filopodium]
GO:0030315 [T-tubule]
GO:0030855 [epithelial cell differentiation]
GO:0030863 [cortical cytoskeleton]
GO:0030953 [astral microtubule organization]
GO:0031528 [microvillus membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0032532 [regulation of microvillus length]
GO:0032587 [ruffle membrane]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034629 [cellular protein complex localization]
GO:0035088 [establishment or maintenance of apical/basal cell polarity]
GO:0036064 [ciliary basal body]
GO:0036398 [TCR signalosome]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042995 [cell projection]
GO:0043209 [myelin sheath]
GO:0043622 [cortical microtubule organization]
GO:0044297 [cell body]
GO:0044393 [microspike]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0044853 [plasma membrane raft]
GO:0045121 [membrane raft]
GO:0045177 [apical part of cell]
GO:0046847 [filopodium assembly]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051117 [ATPase binding]
GO:0051286 [cell tip]
GO:0051660 [establishment of centrosome localization]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071320 [cellular response to cAMP]
GO:0071944 [cell periphery]
GO:0072697 [protein localization to cell cortex]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097449 [astrocyte projection]
GO:0097454 [Schwann cell microvillus]
GO:0098592 [cytoplasmic side of apical plasma membrane]
GO:1900041 [negative regulation of interleukin-2 secretion]
GO:1902115 [regulation of organelle assembly]
GO:1902896 [terminal web assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903753 [negative regulation of p38MAPK cascade]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
586 aa
69.4 kDa
No 0
EZR-002
ENSP00000338934
ENST00000337147
P15311 [Direct mapping]
Ezrin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001726 [ruffle]
GO:0001772 [immunological synapse]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0022614 [membrane to membrane docking]
GO:0030033 [microvillus assembly]
GO:0030175 [filopodium]
GO:0030863 [cortical cytoskeleton]
GO:0030953 [astral microtubule organization]
GO:0031528 [microvillus membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034629 [cellular protein complex localization]
GO:0036398 [TCR signalosome]
GO:0042995 [cell projection]
GO:0043622 [cortical microtubule organization]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0044853 [plasma membrane raft]
GO:0045177 [apical part of cell]
GO:0046847 [filopodium assembly]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051117 [ATPase binding]
GO:0051660 [establishment of centrosome localization]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071320 [cellular response to cAMP]
GO:0071944 [cell periphery]
GO:0072697 [protein localization to cell cortex]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0098592 [cytoplasmic side of apical plasma membrane]
GO:1900041 [negative regulation of interleukin-2 secretion]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903753 [negative regulation of p38MAPK cascade]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
586 aa
69.4 kDa
No 0
EZR-201
ENSP00000376016
ENST00000392177
E7EQR4 [Direct mapping]
Ezrin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
586 aa
69.4 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.