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AGO1

GENERAL INFORMATION

Gene name

 AGO1

Gene description

 Argonaute RISC catalytic component 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AGO1 (HGNC Symbol)

Synonyms

 EIF2C1, hAGO1

Description

 Argonaute RISC catalytic component 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 35869808 - 35930528

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092847 (version 83.38)

Entrez gene

 26523

UniProt

 Q9UL18 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL18

Antibodypedia

 AGO1 antibodies

PROTEIN BROWSER
AGO1-001
AGO1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGO1-001
ENSP00000362302
ENST00000373206
Q5TA58 [Direct mapping]
Protein argonaute
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
Show all
 782 aa
88.9 kDa 		No 0
AGO1-002
ENSP00000362300
ENST00000373204
Q9UL18 [Direct mapping]
Protein argonaute-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000993 [RNA polymerase II core binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0006351 [transcription, DNA-templated]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0010586 [miRNA metabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016442 [RISC complex]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035068 [micro-ribonucleoprotein complex]
GO:0035194 [posttranscriptional gene silencing by RNA]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070578 [RISC-loading complex]
Show all
 857 aa
97.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.