Cell atlas - CECR1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CECR1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CECR1
Gene description	Cat eye syndrome chromosome region, candidate 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (MOLT-4, U-937, Karpas-707)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MOLT-4, U-937, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CECR1 (HGNC Symbol)
Synonyms	ADGF, IDGFL
Description	Cat eye syndrome chromosome region, candidate 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	22
Cytoband	q11.1
Chromosome location (bp)	17178790 - 17221989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000093072 (version 83.38)
Entrez gene	51816
UniProt	Q9NZK5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZK5
Antibodypedia	CECR1 antibodies

PROTEIN BROWSER

CECR1-001	CECR1-002	CECR1-003	CECR1-004	CECR1-005	CECR1-201	CECR1-202	CECR1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CECR1-001 ENSP00000442482 ENST00000543038	F5H7J3 [Direct mapping] Adenosine deaminase CECR1 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0008083 [growth factor activity] GO:0043103 [hypoxanthine salvage] GO:0046103 [inosine biosynthetic process] Show all	152 aa 17.5 kDa	Yes	0
CECR1-002 ENSP00000382733 ENST00000399839	Q9NZK5 [Direct mapping] Adenosine deaminase CECR1 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004000 [adenosine deaminase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006154 [adenosine catabolic process] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008270 [zinc ion binding] GO:0019239 [deaminase activity] GO:0031685 [adenosine receptor binding] GO:0042803 [protein homodimerization activity] GO:0043103 [hypoxanthine salvage] GO:0043394 [proteoglycan binding] GO:0044267 [cellular protein metabolic process] GO:0046103 [inosine biosynthetic process] Show all	511 aa 58.9 kDa	Yes	0
CECR1-003 ENSP00000262607 ENST00000262607	Q9NZK5 [Direct mapping] Adenosine deaminase CECR1 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004000 [adenosine deaminase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006154 [adenosine catabolic process] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008270 [zinc ion binding] GO:0019239 [deaminase activity] GO:0031685 [adenosine receptor binding] GO:0042803 [protein homodimerization activity] GO:0043103 [hypoxanthine salvage] GO:0043394 [proteoglycan binding] GO:0044267 [cellular protein metabolic process] GO:0046103 [inosine biosynthetic process] Show all	511 aa 58.9 kDa	Yes	0
CECR1-004 ENSP00000332871 ENST00000330232	Q9NZK5 [Direct mapping] Adenosine deaminase CECR1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004000 [adenosine deaminase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006154 [adenosine catabolic process] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008270 [zinc ion binding] GO:0019239 [deaminase activity] GO:0031685 [adenosine receptor binding] GO:0042803 [protein homodimerization activity] GO:0043103 [hypoxanthine salvage] GO:0043394 [proteoglycan binding] GO:0044267 [cellular protein metabolic process] GO:0046103 [inosine biosynthetic process] Show all	270 aa 30.7 kDa	No	0
CECR1-005 ENSP00000392078 ENST00000441548	C9IZA8 [Direct mapping] Adenosine deaminase CECR1 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0008083 [growth factor activity] GO:0043103 [hypoxanthine salvage] GO:0046103 [inosine biosynthetic process] Show all	135 aa 15.5 kDa	Yes	0
CECR1-201 ENSP00000382731 ENST00000399837	Q9NZK5 [Direct mapping] Adenosine deaminase CECR1 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004000 [adenosine deaminase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006154 [adenosine catabolic process] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008270 [zinc ion binding] GO:0019239 [deaminase activity] GO:0031685 [adenosine receptor binding] GO:0042803 [protein homodimerization activity] GO:0043103 [hypoxanthine salvage] GO:0043394 [proteoglycan binding] GO:0044267 [cellular protein metabolic process] GO:0046103 [inosine biosynthetic process] Show all	511 aa 58.9 kDa	Yes	0
CECR1-202 ENSP00000406443 ENST00000449907	B4E3Q4 [Direct mapping] Adenosine deaminase CECR1; cDNA FLJ58672, highly similar to Cat eye syndrome critical region protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0008083 [growth factor activity] GO:0019239 [deaminase activity] GO:0043103 [hypoxanthine salvage] GO:0046103 [inosine biosynthetic process] Show all	469 aa 54.4 kDa	No	0
CECR1-203 ENSP00000483418 ENST00000610390	A0A087X0I3 [Direct mapping] Adenosine deaminase CECR1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0008083 [growth factor activity] GO:0019239 [deaminase activity] GO:0043103 [hypoxanthine salvage] GO:0046103 [inosine biosynthetic process] Show all	391 aa 45.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.